Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2,5-Diphenyloxazole, is researched, Molecular C15H11NO, CAS is 92-71-7, about Enantioselective olefin hydrocyanation without cyanide.Quality Control of 2,5-Diphenyloxazole.
The enantioselective hydrocyanation of olefins represents a conceptually straightforward approach to prepare enantiomerically enriched nitriles. These, in turn, comprise or are intermediates in the synthesis of many pharmaceuticals and their synthetic derivatives Herein, we report a cyanide-free dual Pd/CuH-catalyzed protocol for the asym. Markovnikov hydrocyanation of vinyl arenes and the anti-Markovnikov hydrocyanation of terminal olefins in which oxazoles function as nitrile equivalent After an initial hydroarylation process, the oxazole substructure was deconstructed using a [4 + 2]/retro-[4 + 2] sequence to afford the enantioenriched nitrile product under mild reaction conditions.
As far as I know, this compound(92-71-7)Quality Control of 2,5-Diphenyloxazole can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica