Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 83435-58-9, is researched, Molecular C10H19NO3, about A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970), the main research direction is serotoninergic 5HT7 antagonist pyrrolidinesulfonylphenol derivative preparation.Application of 83435-58-9.
The authors recently reported the synthesis and biol. activity of the sulfonamide I, the first potent 5-HT7 receptor antagonist with 100-fold selectivity over a wide range of receptors. More recently a series of tetrahydrobenzindoles have been reported as potent 5-HT7 receptor antagonists, although selectivity over 5-HT2 receptors was only 50-fold. In this communication, the authors report the further optimization of I by conformational restraint of the side chain which has led to more potent and selective compounds, exemplified by II. II was evaluated in a functional model of 5-HT7 receptor activation by examination of adenylyl cyclase activity in HEK 293 cells stably expressing the human 5-HT7(a) receptor.
As far as I know, this compound(83435-58-9)Application of 83435-58-9 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica