The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Boc-D-Prolinol(SMILESS: O=C(N1[C@@H](CO)CCC1)OC(C)(C)C,cas:83435-58-9) is researched.Computed Properties of C15H11NO. The article 《Identification and Structure-Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:83435-58-9).
New members of a previously reported series of 3-pyridyl ether compounds are disclosed as novel, potent analgesic agents acting through neuronal nicotinic acetylcholine receptors. Both (R)-2-chloro-5-(2-azetidinylmethoxy)pyridine (ABT-594, I) and its S-enantiomer (II) show potent analgesic activity in the mouse hot-plate assay following either i.p. (i.p.) or oral (po) administration, as well as activity in the mouse abdominal constriction (writhing) assay, a model of persistent pain. Compared to the S-enantiomer and to the prototypical potent nicotinic analgesic agent (±)-epibatidine (III), I shows diminished activity in models of peripheral side effects. Structure-activity studies of analogs related to I and II suggest that the N-unsubstituted azetidine moiety and the 2-chloro substituent on the pyridine ring are important contributors to potent analgesic activity.
As far as I know, this compound(83435-58-9)Name: Boc-D-Prolinol can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica