Quality Control of 1-Aminopyrrole-2-carboxamide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-Aminopyrrole-2-carboxamide, is researched, Molecular C5H7N3O, CAS is 159326-69-9, about Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ-PI3Kδ Dual Inhibitors. Author is Jia, Hong; Dai, Guangxiu; Su, Weiguo; Xiao, Kun; Weng, Jianyang; Zhang, Zhulin; Wang, Qing; Yuan, Tianhai; Shi, Fuying; Zhang, Zheng; Chen, Wei; Sai, Yang; Wang, Jian; Li, Xiong; Cai, Yu; Yu, Jun; Ren, Ping; Venable, Jennifer; Rao, Tadimeti; Edwards, James P.; Bembenek, Scott D..
An electronic d. model was developed and used to identify a novel pyrrolotriazinone replacement for a quinazolinone, a commonly used moiety to impart selectivity in inhibitors for PI3Kγ and PI3Kδ. Guided by mol. docking, this new specificity piece was then linked to the hinge-binding region of the inhibitor using a novel cyclic moiety. Further structure-activity relationship optimization around the hinge region led to the discovery of candidate 26, a highly potent and selective PI3Kγ-PI3Kδ dual inhibitor with favorable drug metabolism and pharmacokinetic properties in preclin. species.
As far as I know, this compound(159326-69-9)Quality Control of 1-Aminopyrrole-2-carboxamide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica