Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Boc-D-Prolinol, is researched, Molecular C10H19NO3, CAS is 83435-58-9, about Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of [18F]ENL30: A Potential PET Radiotracer for the 5-HT7 Receptor.Recommanded Product: Boc-D-Prolinol.
The 5-HT7 receptor (5-HT7R) is involved in a broad range of physiol. conditions and disorders. Currently, there is no validated clin. positron emission tomog. (PET) tracer available; however, we have recently developed a promising 11C-labeled candidate. In this project, we aimed to further extend our efforts and develop an 18F-labeled derivative, coined [18F]ENL30. Fluorine-18 has several advantages over carbon-11 especially within the preclin. phase, where a long half-life usually increases evaluation throughput. ENL30 was successfully synthesized in a low albeit sufficient overall yield. Radiolabeling succeeded with a radiochem. yield of approx. 4.5%. Subsequent preclin. PET studies revealed that [18F]ENL30 binds specifically to the 5-HT7R but suffered from affinity to σ-receptors. Addnl., we identified [18F]ENL30 to be a P-gp substrate in rats. However, we believe that [18F]ENL30 may prove to be valuable in higher species that exhibit decreased P-gp dependency. If required, σ-receptor binding could, in such studies, be selectively blocked potentially allowing for selective 5-HT7R imaging.
Although many compounds look similar to this compound(83435-58-9)Recommanded Product: Boc-D-Prolinol, numerous studies have shown that this compound(SMILES:O=C(N1[C@@H](CO)CCC1)OC(C)(C)C), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica