Ball, Matthew; Boyd, Alistair; Ensor, Gareth J.; Evans, Matthew; Golden, Michael; Linke, Simon R.; Milne, David; Murphy, Rebecca; Telford, Alex; Kalyan, Yuriy; Lawton, Graham R.; Racha, Saibaba; Ronsheim, Melanie; Zhou, Shao Hong published the article 《Development of a Manufacturing Route to Avibactam, a β-Lactamase Inhibitor》. Keywords: avibactam preparation.They researched the compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide( cas:1416134-49-0 ).HPLC of Formula: 1416134-49-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1416134-49-0) here.
Process development work to provide an efficient, robust, and cost-effective manufacturing route to avibactam, a β-lactamase inhibitor is presented herewith. Aspects of this optimization work include the counterintuitive introduction of a protecting group to effect a difficult urea formation and the use of controlled feed hydrogenation conditions to facilitate an elegant one pot debenzylation and sulfation reaction. Overall, the com. process delivers avibactam in much improved yield with significant reduction in the environmental footprint.
After consulting a lot of data, we found that this compound(1416134-49-0)HPLC of Formula: 1416134-49-0 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica