The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Aminopyrrole-2-carboxamide( cas:159326-69-9 ) is researched.Reference of 1-Aminopyrrole-2-carboxamide.Xiang, Haoyue; Chen, Yanhong; He, Qian; Xie, Yuyuan; Yang, Chunhao published the article 《Pot, atom and step economic synthesis: a diversity-oriented approach to construct 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones》 about this compound( cas:159326-69-9 ) in RSC Advances. Keywords: pyrrolecarboxamide chromonecarboxaldehyde amidine heterocyclization; pyrimidinyl aryl pyrrolotriazinone preparation; chromonecarboxaldehyde pyrrolecarboxamide hydrazine heterocyclization; pyrazolyl aryl pyrrolotriazinone preparation. Let’s learn more about this compound (cas:159326-69-9).
A diversity-oriented approach to the synthesis of pyrimidinyl-/pyrazolyl-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones, e.g., I and II, via copper-promoted two-step one-pot reaction of chromones with pyrrolecarboxamides and amidines/hydrazines was developed. Pot, atom and step economy were combined in these sequential reactions, and at least six bonds were formed in one pot.
After consulting a lot of data, we found that this compound(159326-69-9)Reference of 1-Aminopyrrole-2-carboxamide can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica