Sahu, Pramod K.;Sahu, Praveen K.;Kaurav, Manvendra S.;Messali, Mouslim;Almutairi, Saud M.;Sahu, Puran L.;Agarwal, Dau D. published 《Metal-Free Construction of Fused Pyrimidines via Consecutive C-C and C-N Bond Formation in Water》 in 2018. The article was appeared in 《ACS Omega》. They have made some progress in their research.Synthetic Route of C7H5N3O2S The article mentions the following:
A facile and efficient protocol has been developed for mild construction of fused pyrimidines I (R = Ph, 4-ClC6H4, 2-MeC6H4, etc.) via L-proline catalyzed reaction of 4-hydroxy coumarins, aldehydes and 2-aminobenzothiazoles/urea. Reaction has been carried out rapidly and efficiently in water under mild and metal free conditions. Current etiquette has efficiently synthesized the heterocycles and avoids the use of hazardous solvents over conventional organic solvents. A plausible reaction mechanism has established in this study. This study represents the first case in which L-proline as homogeneous catalyst has been explored in synthesis of fused pyrimidines in water in view of simple procedure and acceptable efficiency. This method gives the target product in excellent yield with ease of workup. And 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) was used in the research process.
6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Synthetic Route of C7H5N3O2S) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica