SDS of cas: 6285-57-0In 2020, Tiwari, Monika R.;Patel, Navin B. published 《Synthesis, characterization and biological studies of thiazolidinone analogues》. 《Journal of Applicable Chemistry (Lumami, India)》published the findings. The article contains the following contents:
A new series of 2-(4-substituted phenyl)-3-(6-substituted benzo [d]thiazol-2-yl)thiazolidin-4-one derivatives I [R = pyridin-4-yl, 4-hydroxy-3-methylphenyl, 4-chlorophenyl, etc.; R1 = MeO, O2N] were prepared by hybridization of two different biol. active moieties benzothiazole and thiazolidinone. The structures of the newly synthesized compounds I were established on the basis of spectral data (IR, 1H and 13C NMR) and elemental anal. All the synthesized compounds I were tested for antibacterial activity against Gram-pos. bacteria (S. aureus, S. pyogenes) and Gram-neg. bacteria (C. albicans, A. niger, A. clavatus), antifungal activity against three fungi (C. albicans, A. niger, A. clavatus) using the MIC (Minimal Inhibitory Concentration) method, anti-tubercular activity H37Rv using L. J. Slope Method. Results of biol. screening revealed that compounds I [R1 = O2N; R = 4-chlorophenyl, 4-methylthiophenyl, 4-methylphenyl, 3-methyl-4-hydroxyphenyl, R1 = MeO; R = 4-fluorophenyl, 4-trifluoromethylphenyl] showed good antibacterial activity where as I [R1 = O2N; 4-chlorophenyl, R1 = MeO, R = furan-2-yl] and showed good antifungal activity and compound I [R1 = O2N; R = 4-bromophenyl] showed good antitubercular activity. To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .
6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 SDS of cas: 6285-57-0) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica