Alom, Nur-E.;Kaur, Navdeep;Wu, Fan;Saluga, Shannon Jasmine;Li, Wei published 《Catalytic Regio- and Stereoselective Alkene Sulfenoamination for 1,4-Benzothiazine Synthesis》 in 2019. The article was appeared in 《Chemistry – A European Journal》. They have made some progress in their research.Synthetic Route of C7H5N3O2S The article mentions the following:
An alkene sulfenoamination reaction with 2-aminothiophenol was developed using iodide catalysis. This reaction rendered access to useful 1,4-benzothiazines such as I [R1 = H, Ph, 1-naphthyl, etc.; R2 = H, Me, Ph; R3 = H, Me, n-Pr, n-hexyl, (CH2)2Ph] with good functional group compatibility including both electron-donating and electron-withdrawing substituents. The reaction was proposed to proceeded through an inversion of the polarity of the thiol functionality. Our mechanistic studies revealed that both thiiranium and thiyl radical pathways were plausible and that the disulfide reagent could also function as a viable substrate in this reaction. To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .
6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Synthetic Route of C7H5N3O2S) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica