Parpia, Tarina;Svensen, Erling;Elwood, Sarah;Wanjuhi, Anne;Blacy, Ladislaus;Bayo, Eliwaza;Houpt, Eric;McQuade, Elizabeth Rogawski;DeBoer, Mark;Platts-Mills, James;Mduma, Estomih;Scharf, Rebecca published 《Cognitive outcomes at 18 months: findings from the early life interventions for childhood growth and development in Tanzania (ELICIT) trial》 in 2022. The article was appeared in 《American Journal of Tropical Medicine and Hygiene》. They have made some progress in their research.SDS of cas: 55981-09-4 The article mentions the following:
Micronutrient deficiencies and enteric infections neg. impact child growth and development. We enrolled children shortly after birth in a randomized, placebo-controlled, 2 x 2 factorial interventional trial in Haydom, Tanzania, to assess nicotinamide and/or antimicrobials (azithromycin and nitazoxanide) effect on length at 18 mo of age. Cognitive score at 18 mo using the Malawi Developmental Assessment Tool (MDAT), which includes gross motor, fine motor, language, and social assessments, was a secondary outcome. Here, we present the MDAT results of 1,032 children. There was no effect of nicotinamide (change in development-for-age Z score [DAZ] -0.08; 95% CI: -0.16, 0) or antimicrobials (change in DAZ 0.04; 95% CI: -0.06, 0.13) on overall MDAT score. The interventions had no effect on cognitive outcomes in subgroups defined by gender, socioeconomic status, birthweight, and birth season or on MDAT subscores. Further analyses are needed to identify targetable risk factors for impaired cognitive development in these settings. The experimental procedure involved many compounds, such as 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate (cas: 55981-09-4) .
2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate(cas: 55981-09-4), a thiazolide compound, is a antiparasitic drug with structure similar to niclosamide.SDS of cas: 55981-09-4
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica