Name: 6-Nitrobenzo[d]thiazol-2-amine《Synthesis, Characterization and Biological Evaluation of 2-(p-Nitrophenyl)quinazolin-4(3H)-one Derivatives》 was published in 2020. The authors were Giradkar, V. N.;Kabra, U. D.;Diwakar, R. S.;Lohiya, R. T.;Umekar, M. J., and the article was included in《Russian Journal of Organic Chemistry》. The author mentioned the following in the article:
A series of novel 2-(4-nitrophenyl)-3-(R-benzothiazol-2-yl)quinazolin-4(3H)-ones I [R = H, 5-Br, 6-NO2, etc.] was synthesized from the 2-aminobenzothiazoles and 2-(4-nitrophenyl)-4H-3,1-benzoxazin-4-one via a nucleophilic addition reaction. The synthesized compounds I were tested for anticonvulsant, antimicrobial, and antioxidant activities. All the compounds I increased the seizure latency compared to control. Compound I [R = 6-NO2] exhibited significant anticonvulsant activity, comparable to that of the standard drug Phenytoin. Antimicrobial activity testing revealed moderate to good activity in all the test compounds, I and I [R = H, 6-NO2] compared in activity with the standard drug Chloramphenicol. The antioxidant activity of compounds I [R = H], I [R = 5-Br] and I [ R = 4,6-Me2] IC50 39.30, 15.55, and 42.95μg/mL, resp. was found to be higher compared to the standard drug ascorbic acid (IC50 48.30μg/mL). To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .
6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Name: 6-Nitrobenzo[d]thiazol-2-amine) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica