Pavan Phani Kumar, M.;Anuradha, V.;Subramanyam, Ch.;Hari Babu, V. V. published 《In silico molecular docking study, synthesis and α-amylase inhibitory activity evaluation of phosphorylated derivatives of purine》 in 2021. The article was appeared in 《Phosphorus, Sulfur and Silicon and the Related Elements》. They have made some progress in their research.Reference of 6-Nitrobenzo[d]thiazol-2-amine The article mentions the following:
A series of phosphorylated derivatives of purine were synthesized in good yields (88-95%) by the reaction of 2-chloro-4-{[(9H-purin-9-yl)methoxy]methyl}-1,3,2-λ5-dioxaphospholan-2-one with various heterocyclic amines. In silico mol. docking study was performed for all the designed compounds to assess their potential ability to inhibit the pancreatic α-amylase enzyme. The compounds (6a–6j) with good inhibition toward the target enzyme were prompted for the synthesis. Spectroscopic analyses of all the newly synthesized compounds were performed to confirm their structures. In vitro α-amylase inhibitory activity of the synthesized compounds was also carried out using acarbose as a standard drug. The compounds 2-[(6-chloro-1,3-benzothiazol-2-yl)amino]-4-{[(9H-purin-9-yl)methoxy]methyl}-1,3,2λ5-dioxaphospholan-2-one (6j) (IC50, 94.3 ± 0.5μg/mL) and 1-methyl-6-[(2-oxo-4-{[(9H-purin-9-yl)methoxy]methyl}-1,3,2λ5-dioxaphospholan-2-yl)amino]-1,2,3,4-tetrahydropyrimidine-2,4-dione (6f) (IC50, 99.0 ± 0.4μg/mL) reported the highest inhibition among the synthesized compounds All the remaining compounds exhibited good to moderate inhibition with IC50 values in the range of 102.9 ± 0.6 to 233.5 ± 0.6μg/mL when compared with the standard drug, acarbose (IC50, 50.47 ± 0.28μg/mL). The experimental procedure involved many compounds, such as 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .
6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Reference of 6-Nitrobenzo[d]thiazol-2-amine) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica