Computed Properties of C18H24N6O6S4On November 30, 2019 ,《The multicopper oxidase of Mycobacterium tuberculosis (MmcO) exhibits ferroxidase activity and scavenges reactive oxygen species in activated THP-1 cells》 appeared in International Journal of Medical Microbiology. The author of the article were Kinkar, Eyad; Kinkar, Ayat; Saleh, Mazen. The article conveys some information:
The MmcO protein of Mycobacterium tuberculosis is a membrane-associated multicopper oxidase. Its natural substrate(s) and its role in pathogenesis are not well characterized. A recent report proposes that MmcO contributes to copper resistance in M. tuberculosis during infection. We have expressed and reconstituted the active enzyme from inclusion bodies in E. coli. MmcO exhibits maximal activity against the exptl. substrate 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) or ABTS, at pH 4. The enzyme also exhibits ferroxidase activity at pH 4. Most notable was the finding that MmcO is able to scavenge the reactive oxygen species (ROS) generated by the xanthine/xanthine oxidase enzyme system. This ROS scavenging activity of MmcO was also evident against ROS generated by THP-1 cells. We propose that MmcO protects M. tuberculosis during infection against ROS attack in addition to providing copper resistance to the pathogen. The results came from multiple reactions, including the reaction of ABTS Diammonium(cas: 30931-67-0Computed Properties of C18H24N6O6S4)
ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Computed Properties of C18H24N6O6S4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica