Yu, Xiaoling; Zhang, Bingbing; Shan, Guangsheng; Wu, Yue; Yang, Feng-Ling; Lei, Xinsheng published the artcile< Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A>, Product Details of C12H18N2O4S, the main research area is macrocyclic depsipeptide hybrid thiol synthesis HDAC inhibitor antitumor agent; natural product largazole psammaplin A drug design; methylcysteine acylation cyclocondensation thiazole thiazoline hydrolysis; malic acid cyclocondensation trichloro ethanediol esterification amidation; macrolactamization protective group.
One important class of HDAC (histone deacetylation enzymes) inhibitors is the sulfur-containing marine natural products with structural diversity. Inspired by two structurally distinguishing examples, Largazole and Psammaplin A, which possess macrocyclic depsipeptide and simple linear amide scaffold resp., we designed one novel mol. hybrid by replacing the alkene moiety in Largazole with a semirigid amide bond. This hybrid compound has been synthesized from L-malic acid in 10 steps with an overall yield of 7%. The preliminary biol. assays suggest that the replacement of trans olefin moiety with amide bond will lead to an unbeneficial effect on the inhibition against HDACs.
Tetrahedron published new progress about (Fluorenylmethoxy)carbonyl group. 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Product Details of C12H18N2O4S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica