Bodireddy, Mohan Reddy; Mohinuddin, P. Khaja Md.; Gundala, Trivikram Reddy; Reddy, N. C. Gangi published the artcile< Lactic acid-mediated tandem one-pot synthesis of 2-aminothiazole derivatives: a rapid, scalable, and sustainable process>, SDS of cas: 57493-24-0, the main research area is acetophenone thiourea lactic acid catalyst tandem bromination Hantzsch reaction; aminothiazole regioselective preparation green chem.
Environmentally benign and biodegradable lactic acid was identified as alternative solvent and catalyst for the tandem one-pot synthesis of Hantzsch 2-aminothiazole derivatives from readily available aralkyl ketones through in-situ regioselective α-bromination using N-bromosuccinimide followed by heterocyclization using thiourea at 90-100°. The major advantages of the present method include short reaction times (10-15 min), practical, simple to perform, easy work-up, good yield of products (up to 96%), productive for large-scale applications, free from apply of α-bromoketones (lachrymator) as substrates, avoids column purification Hence, the present method met with the concepts of both Wender’s “”ideal synthesis”” and sustainable chem. process.
Cogent Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica