Fagundez, Catherine; Serra, Gloria published the artcile< Studies on synthesis of amino acid derived thiazoles. Preparation of bis-thiazoles as key fragments of aerucyclamide analogs>, Formula: C12H18N2O4S, the main research area is thiazole bisthiazole preparation.
The scope and limitations of Hantzsch, modified Hantzsch and Kelly methodologies for the synthesis of amino acid derived thiazoles are presented. In addition, the syntheses of bisthiazoles as key fragments of natural products and analogs are described. The Kelly’s methodol. followed by oxidation provides the desired N-Cbz protected thiazole after purification According with the authors’ results the Fmoc or Boc protecting groups are not compatible with the conditions used in this methodol. Modifications of the temperature and reagents used in the Hantzsch thiazole synthesis enabled the preparation of chiral thiazole building blocks without racemization and in good yields.
Heterocyclic Letters published new progress about 96929-05-4. 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Formula: C12H18N2O4S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica