Krasitskaya, Vasilisa V.; Bashmakova, Eugenia E.; Frank, Ludmila A. published the artcile< Coelenterazine-dependent luciferases as a powerful analytical tool for research and biomedical applications>, Synthetic Route of 2591-17-5, the main research area is review coelenterazine luciferase bioluminescent system; Ca2+-regulated photoprotein; analytical systems; bioluminescence; coelenterazine; luciferase.
A review. The functioning of bioluminescent systems in most of the known marine organisms is based on the oxidation reaction of the same substrate-coelenterazine (CTZ), catalyzed by luciferase. Despite the diversity in structures and the functioning mechanisms, these enzymes can be united into a common group called CTZ-dependent luciferases. Among these, there are two sharply different types of the system organization-Ca2+-regulated photoproteins and luciferases themselves that function in accordance with the classical enzyme-substrate kinetics. Along with deep and comprehensive fundamental research on these systems, approaches and methods of their practical use as highly sensitive reporters in analytics have been developed. The research aiming at the creation of artificial luciferases and synthetic CTZ analogs with new unique properties has led to the development of new exptl. anal. methods based on them. The com. availability of many ready-to-use assay systems based on CTZ-dependent luciferases is also important when choosing them by first-time-users. The development of anal. methods based on these bioluminescent systems is currently booming. The bioluminescent systems under consideration were successfully applied in various biol. research areas, which confirms them to be a powerful anal. tool. In this , we consider the main directions, results, and achievements in research involving these luciferases.
International Journal of Molecular Sciences published new progress about 2591-17-5. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Synthetic Route of 2591-17-5.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica