Patel, Vimal I’s team published research in Asian Journal of Research in Chemistry in 2009-12-31 | 57493-24-0

Asian Journal of Research in Chemistry published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Reference of 57493-24-0.

Patel, Vimal I.; Patel, Harsha U.; Patel, Chhaganbhai N.; Suthar, Kiran J. published the artcile< Synthesis and anti-bacterial study of 4-(4-substituted phenyl)-5,6-disubstituted-1-(4-substituted phenylthiazol-2-yl)pyridin-2(1H)-one>, Reference of 57493-24-0, the main research area is pyridinone arylthiazolyl preparation antibacterial.

4-(4-Substituted phenyl)-5,6-disubstituted-1-(4-substituted phenylthiazol-2-yl)pyridin-2(1H)-ones have been prepared from citric acid. It is treated with concentrate H2SO4 and then with phenetole to give β-arylglutaconic acid which on fusion with 2-amino 4-substituted phenylthiazole gave 4-(substituted phenyl)-1-1(4-substituted phenylthiazol-2-yl)pyridine-2,6(1H,3H)-dione. Then reaction with phosphorus oxychloride gave 5,6-dichloro-4-(4-substituted phenyl)-1-(4-substituted phenylthiazol-2-yl)pyridin-2(1H)-one. This, on treatment with secondary amines, yields 4-(4-substituted phenyl)-5,6-disubstituted-1-(4-substituted-phenylthiazol-2-yl)pyridin-2(1H)-one. All the title compounds characterized on the basis of their IR, MASS, 1H NMR spectroscopic data anal.

Asian Journal of Research in Chemistry published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Reference of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica