Pola, Robert; Kral, Vlastimil; Filippov, Sergey K.; Kaberov, Leonid; Etrych, Tomas; Sieglova, Irena; Sedlacek, Juraj; Fabry, Milan; Pechar, Michal published the artcile< Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells>, SDS of cas: 96-53-7, the main research area is polymer tumor targeting antibody ganglioside GD2.
A water-soluble polymer cancerostatic actively targeted against cancer cells expressing a disialoganglioside antigen GD2 was designed, synthesized and characterized. A polymer conjugate of an antitumor drug doxorubicin with a N-(2-hydroxypropyl)methacrylamide-based copolymer was specifically targeted against GD2 antigen-pos. tumor cells using a recombinant single chain fragment (scFv) of an anti-GD2 monoclonal antibody. The targeting protein ligand was attached to the polymer-drug conjugate either via a covalent bond between the amino groups of the protein using a traditional nonspecific aminolytic reaction with a reactive polymer precursor or via a noncovalent but highly specific interaction between bungarotoxin covalently linked to the polymer and the recombinant scFv modified with a C-terminal bungarotoxin-binding peptide. The GD2 antigen binding activity and GD2-specific cytotoxicity of the targeted noncovalent polymer-scFv complex proved to be superior to the covalent polymer-scFv conjugate.
Biomacromolecules published new progress about Antibody-drug conjugates. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, SDS of cas: 96-53-7.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica