Product Details of 97817-23-7On June 4, 2019, Chevillard, Florent; Stotani, Silvia; Karawajczyk, Anna; Hristeva, Stanimira; Pardon, Els; Steyaert, Jan; Tzalis, Dimitrios; Kolb, Peter published an article in Proceedings of the National Academy of Sciences of the United States of America. The article was 《Interrogating dense ligand chemical space with a forward-synthetic library》. The article mentions the following:
Forward-synthetic databases are an efficient way to enumerate chem. space. The authors explored here whether these databases are good sources of novel protein ligands and how many mols. are obtainable and in which time frame. Based on docking calculations, series of mols. were selected to gain insights into the ligand structur-activity relation. To evaluate the novelty of compounds in a challenging way, the authors chose the β2-adrenergic receptor, for which a large number of ligands is already known. Finding dissimilar ligands is thus the exception rather than the rule. Here the authors report on the results, the successful synthesis of 127/240 mols. in just 2 wk, the discovery of previously unreported dissimilar ligands of the β2-adrenergic receptor, and the optimization of one series to a KD of 519 nM in only one round. Moreover, the finding that only 3 of 240 mols. had ever been synthesized before indicates that large parts of chem. space are unexplored. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine(cas: 97817-23-7Product Details of 97817-23-7)
4,5,6,7-Tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine(cas: 97817-23-7) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Product Details of 97817-23-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica