Geary, Gemma C.; Nortcliffe, Andrew; Pearce, Christopher A.; Hamza, Daniel; Jones, Geraint; Moody, Christopher J. published the artcile< Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery>, Recommanded Product: Thiazole-5-carboxyaldehyde, the main research area is spirocyclic oxetane piperidine scaffold preparation rearrangement gold catalyst.
A spirocyclic, sp3-atom rich oxetane-containing scaffold was synthesized in just two steps via a gold catalyzed propargylic alc. rearrangement. The key gold cyclization can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lead Factory.
Bioorganic & Medicinal Chemistry published new progress about Oxetanes Role: SPN (Synthetic Preparation), PREP (Preparation) (spirocyclic). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Recommanded Product: Thiazole-5-carboxyaldehyde.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica