Gromek, Samantha M.; deMayo, James A.; Maxwell, Andrew T.; West, Ashley M.; Pavlik, Christopher M.; Zhao, Ziyan; Li, Jin; Wiemer, Andrew J.; Zweifach, Adam; Balunas, Marcy J. published the artcile< Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity>, SDS of cas: 57493-24-0, the main research area is santacruzamate A analog preparation antiproliferative immunomodulator; Anti-proliferative activity; Enzyme assays; Immune modulation; Natural product analogues; Santacruzamate A.
Santacruzamate A (SCA) is a natural product isolated from a Panamanian marine cyanobacterium, previously reported to have potent and selective histone deacetylase (HDAC) activity. To optimize the enzymic and cellular activity, 40 SCA analogs were synthesized in a systematic exploration of the zinc-binding group (ZBG), cap terminus, and linker region. Two cap group analogs inhibited proliferation of MCF-7 breast cancer cells, with analogous increased degranulation of cytotoxic T cells (CTLs), while one cap group analog reduced CTL degranulation, indicative of suppression of the immune response. Addnl. testing of these analogs resulted in reevaluation of the previously reported SCA mechanism of action. These analogs and the resulting structure-activity relationships will be of interest for future studies on cell proliferation and immune modulation.
Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica