Formula: C3H3BrN2SIn 2012 ,《Microwave-promoted synthesis and antimicrobial activity of 3-thiazole substituted 2-styryl-4(3H)-quinazolinone derivatives》 was published in Journal of Saudi Chemical Society. The article was written by Jagani, Chandresh L.; Sojitra, Natvar A.; Vanparia, Satish F.; Patel, Tarosh S.; Dixit, Ritu B.; Dixit, Bharat C.. The article contains the following contents:
The present paper described an optimized reaction condition for the microwave-promoted synthesis of newer 3-thiazole-substituted 2-styryl-4(3H)-quinazolinone derivatives, which in turn were prepared in good yield by the treatment of various 2-styrylbenzoxazinone derivatives with various 2-aminothiazoles using co-solvent under microwave irradiation All the compounds were characterized by various spectroscopic techniques and anal. methods. All newly synthesized compounds were screened for their in vitro antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus megaterium, Bacillus subtilis, and Aspergillus niger. In the experimental materials used by the author, we found 5-Bromothiazol-2-amine(cas: 3034-22-8Formula: C3H3BrN2S)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Formula: C3H3BrN2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica