Kamble, Sonali S.; Hese, Shrikant V.; Dawane, Bhaskar S.; Gacche, Rajesh N. published the artcile< Anti-breast cancer and antiangiogenic potential of substituted thiazolo[2,3-b] quinazoline derivatives: synthesis, in vitro and in vivo analysis>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is thiazolo quinazoline derivative antibreast cancer antiangiogenic potential.
Herein, a series of novel substituted thiazolo[2,3-b]quinazoline derivatives has been synthesized. The capability of the synthesized compounds 3a-i to hinder the viability of human breast cancer cell line (MCF-7) was assessed. The compounds were evaluated as possible inhibitors of angiogenesis by using in vivo chorioallantoic membrane (CAM) model. Amongst the compounds 3a-i screened, 3d and 3f exhibited excellent cytotoxicity with IC50 values 6.0±0.03μM & 5.0±0.36μM resp. Compounds were further tested to evaluate potential to inhibit the pro-angiogenic cytokines associated with tumor development. Both the compounds were found to be potent antiangiogenic agents against VEGF, TNFa, IL6, TGFb, and EGF. The outcome of the present study reveals that, compound 3d and 3f showed the promising inhibitory activity on the viability of MCF-7 cells. In the in vivo CAM model, treatment with all the compounds resulted in the significant decrease in blood vessels d. The findings of the study suggest that, compounds 3d & 3f may act as potential anti-breast cancer and antiangiogenic agents.
Chemistry & Biology Interface published new progress about Angiogenesis. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica