In 2016,Li, Hongshuang; Wang, Xinran; Duan, Guiyun; Xia, Chengcai; Xiao, Yuliang; Li, Furong; Ge, Yanqing; You, Guirong; Han, Junfen; Fu, Xiaopan; Tan, Shanhui; Wang, Rongwei published 《Synthesis, antitumor activity and preliminary structure-activity relationship of 2-aminothiazole derivatives》.Chemical Research in Chinese Universities published the findings.Computed Properties of C3H3BrN2S The information in the text is summarized as follows:
In this paper, we described the synthesis of 2-aminothiazole sublibrary containing Me, bromo, Ph or butylidene at 4- or/and 5-position of its core. All target compounds were evaluated for their antitumor activities against human lung cancer cell line H1299 and human glioma cell line SHG-44. Among the compounds screened, 4,5,6,7-tetrahydrobenzo[d]thiazole(26b) exhibited the most potent antitumor activities with IC50 values of 4.89 and 4.03 μmol/L against the two tested cell lines, resp. Preliminary structure-activity relationship(SAR) studies of these compound were subsequently investigated. In the experiment, the researchers used 5-Bromothiazol-2-amine(cas: 3034-22-8Computed Properties of C3H3BrN2S)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Computed Properties of C3H3BrN2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica