The author of 《Synthesis and antimicrobial evaluation of benzothiazole linked isoxazole Schiff bases》 were Mallikarjun, G.; Raju, A. Krishnam; Yadav, J. S.. And the article was published in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 2021. SDS of cas: 95-24-9 The author mentioned the following in the article:
A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared I [R = R1 = H, OMe, RR1 = -OCH2O-, R2 = H, OMe; R3 = 5-Cl, 4-OMe, 6-CF3, etc.] characterized by suitable spectroscopic methods via 1H and 13C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds [R = R1 = OMe, R2 = H, R3 = 6-Me (II); R = H, R1 = OMe, R2 = H, R3 = 6-OMe (III); R = R1 = R2 = OMe, R3 = 6-F (IV)] demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 – 62.5μg/mL. Further, compounds II, III and IV exhibit promising antifungal activity with MIC values ranging between 7.8 – 32.5μg/mL. Further studies are underway for determining the antifungal mol. mechanisms of these potential compounds In the experiment, the researchers used many compounds, for example, 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9SDS of cas: 95-24-9)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.SDS of cas: 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica