Mandal, Subhankar P.; Mithuna; Garg, Aakriti; Sahetya, Sanjana S.; Nagendra, S. R.; Sripad, H. S.; Manjunath, Mendon Manisha; Sitaram; Soni, Mukesh; Baig, R. Nasir; Kumar, S. Vasanth; Kumar, B. R. Prashantha published the artcile< Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study>, COA of Formula: C10H9NOS2, the main research area is rhodanine anticancer agent breast cancer cell QSAR.
Three different series of some novel N-substituted rhodanines were designed for anticancer activity and prepared from the corresponding dithiocarbamates. The synthesized compounds were analyzed by IR, NMR and MASS to confirm their structures. All the titled compounds were found to be of Z configuration based on NMR spectral anal. All the synthesized rhodanines were screened for in vitro anticancer activity against MCF-7 breast cancer cells at the concentration of 10 μg. The compounds showed moderate to significant cytotoxicity. Amongst them, interestingly, compounds 10, 22 and 33 with cinnamoyl substitution at the 5th position of the thiazolidine ring system showed significant activity. Further, we subjected all these compounds to a CoMSIA study to study their 3D quant. structure activity relationships (3D QSAR). The illustration about the design of novel rhodanines, synthesis, anal., activity against MCF-7 cells and SAR via CoMSIA study are reported here.
RSC Advances published new progress about Antitumor agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, COA of Formula: C10H9NOS2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica