《Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide》 was published in Chemistry – A European Journal in 2018. These research results belong to Mukhopadhyay, Sushobhan; Batra, Sanjay. Synthetic Route of C7H3BrClNS The article mentions the following:
A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimides (NXS) in DMF at room temperature under metal- and acid-free condition was described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide. In the experimental materials used by the author, we found 2-Bromo-4-chlorobenzo[d]thiazole(cas: 3622-40-0Synthetic Route of C7H3BrClNS)
2-Bromo-4-chlorobenzo[d]thiazole(cas: 3622-40-0) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Synthetic Route of C7H3BrClNSTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica