《Phytochemical profile and comparative anti-radical scavenging activities of n-hexane extracts of indigenous Zingiber officinale and Curcuma longa》 was written by Nweze, Chibuzo Carole; Dingwoke, Emeka John; Adamude, Fatima Amin; Nwobodo, Nwobodo Ndubuisi. Synthetic Route of C18H24N6O6S4 And the article was included in Free Radicals and Antioxidants in 2019. The article conveys some information:
Objectives: Free radical scavenging activities of n-haxane extracts of indigenous Curcuma longa and Zingiber officinale was investigated and compared to CellGevity; a nutraceutical antioxidant supplement. Methods: We used 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, 2,2′-Azino-bis3-ethylbenzothialine-6-sulfonic acid (ABTS) radical cations and hydrogen peroxide (H2O2) to determine free radical scavenging activities of the extracts The ability of the extracts to scavenge free radicals was determined following the discoloration of the solution mixtures, measured spectrophotometrically. The reducing power efficacy of the extracts was determined by their ability to reduce Fe3+ to Fe2+ ions. Results:Curcuma longa and Zingiber officinale have more free radical scavenging power compared to CellGevity. Curcuma longa has more scavenging power against DPPH and H2O2 system, while Zingiber officinale has more scavenging power against ABTS cations. CellGevity had the least scavenging activity against the free radicals, as observed in this study. The highest phenolic, flavonoid, Vitamin C, Vitamin B1 and Vitamin B2 quantified were found in Curcuma longa and Zingiber officinale compared to CellGevity. Conclusion: The indigenous Curcuma longa and Zingiber officinale are natural sources of effective antioxidants with more scavenging power compared to a standard CellGevity nutraceutical. In the part of experimental materials, we found many familiar compounds, such as ABTS Diammonium(cas: 30931-67-0Synthetic Route of C18H24N6O6S4)
ABTS Diammonium(cas: 30931-67-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Synthetic Route of C18H24N6O6S4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica