Day: October 13, 2022

HPLC of Formula: 30931-67-0On May 31, 2022, Zhang, Xiaowei; Ren, Xiangrui; Zhao, Xiaoyan; Liu, Hongkai; Wang, Meng; Zhu, Yunping published an article in Journal of the American Oil Chemists’ Society. The article was 《Stability, structure, and antioxidant activity of astaxanthin crystal from Haematococcus pluvialis》. The article mentions the following:

Crystallized anthaxanthin was prepared through the cleaning crystallization method and the stabilities during thermal, lighting, and pH treatment, and antioxidant activities in vitro were evaluated. The structural characterizations of astaxanthin crystal were verified by 1H, 13C NMR, and XRD anal. The stability data showed that the astaxanthin crystal was more sensitive to heat, light, and pH compared to oleoresin. The sucrose had no outstanding influence on the astaxanthin crystal, while the stability of astaxanthin oleoresin slightly increased with the increase of sugar concentration The XRD and NMR spectra elucidated that the astaxanthin crystal was all trans structure. The astaxanthin crystal showed the dominant 1,1′-diphenyl-2-picrylhydrazyl (IC50 18.65μmol L-1), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt +(21.1μmol L-1), •OH (IC50 49.46μmol L-1) and ferric reducing antioxidant power (IC50 81.60μmol L-1) activities. The investigated results would be helpful for improving the development of astaxanthin crystal in food products. In the experimental materials used by the author, we found ABTS Diammonium(cas: 30931-67-0HPLC of Formula: 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.HPLC of Formula: 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pollack, Scott J.; Beyer, Kim S.; Lock, Christopher; Mueller, Ilka; Sheppard, David; Lipkin, Mike; Hardick, David; Blurton, Peter; Leonard, Philip M.; Hubbard, Paul A.; Todd, Daniel; Richardson, Christine M.; Ahrens, Thomas; Baader, Manuel; Hafenbradl, Doris O.; Hilyard, Kate; Buerli, Roland W. published an article in Journal of Computer-Aided Molecular Design. The title of the article was 《A comparative study of fragment screening methods on the p38α kinase: new methods, new insights》.Application In Synthesis of 6-Morpholinobenzo[d]thiazol-2-amine The author mentioned the following in the article:

The stress-activated kinase p38α was used to evaluate a fragment-based drug discovery approach using the BioFocus fragment library. Compounds were screened by surface plasmon resonance (SPR) on a Biacore T100 against p38α and two selectivity targets. A sub-set of the library was the focus of detailed follow-up analyses that included hit confirmation, affinity determination on 24 confirmed, selective hits and competition assays of these hits with respect to a known ATP binding site inhibitor. In addition, functional activity against p38α was assessed in a biochem. assay using a mobility shift platform (LC3000, Caliper LifeSciences). A selection of fragments was also evaluated using fluorescence lifetime (FLEXYTE) and microscale thermophoresis (Nanotemper) technologies. A good correlation between the data for the different assays was found. Crystal structures were solved for four of the small mols. complexed to p38α. Interestingly, as determined both by X-ray anal. and SPR competition experiments, three of the complexes involved the fragment at the ATP binding site, while the fourth compound bound in a distal site that may offer potential as a novel drug target site. A first round of optimization around the remotely bound fragment has led to the identification of a series of triazole-containing compounds This approach could form the basis for developing novel and active p38α inhibitors. More broadly, it illustrates the power of combining a range of biophys. and biochem. techniques to the discovery of fragments that facilitate the development of novel modulators of kinase and other drug targets.6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2Application In Synthesis of 6-Morpholinobenzo[d]thiazol-2-amine) was used in this study.

6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application In Synthesis of 6-Morpholinobenzo[d]thiazol-2-amineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Synthesis and biological evaluation of 1-(6-chlorobenzo[d]thiazol-2-yl)-2-(disubstituted methylene)hydrazine derivatives》 were Sharma, Neetesh Kumar; Bhadauria, Raghvendra Singh. And the article was published in Journal of Drug Delivery and Therapeutics in 2019. Computed Properties of C7H5ClN2S The author mentioned the following in the article:

Synthesis of a series of various 1-(6-chlorobenzo[d]thiazol-2-yl)-2-(disubstituted methylene)hydrazine derivatives (E/Z)-I [R1 = Ph, Me; R2 = Ph, Me, Et; R1R2 = -(CH2)5-], (E)-2-(6-chlorobenzo[d]thiazol-2-yl)-1-(7,7-dimethylbicyclo [2.2.1] heptan-2-ylidene) hydrazine and intermediates 6-chloro-2-amine-1,3-benzothiazole and 2-hydrazino-6-chloro-1,3-benzothiazole have been done. After spectral anal., antibacterial activity has been screened against S. aureus and E. coli.6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Computed Properties of C7H5ClN2S) was used in this study.

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Computed Properties of C7H5ClN2STheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2004,Helal, Christopher J.; Sanner, Mark A.; Cooper, Christopher B.; Gant, Thomas; Adam, Mavis; Lucas, John C.; Kang, Zhijun; Kupchinsky, Stanley; Ahlijanian, Michael K.; Tate, Bonnie; Menniti, Frank S.; Kelly, Kristin; Peterson, Marcia published 《Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease》.Bioorganic & Medicinal Chemistry Letters published the findings.Related Products of 3034-22-8 The information in the text is summarized as follows:

High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide. This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC50 = ca. 320 nM). Parallel and directed synthesis techniques were utilized to explore the SAR of this series. Up to 60-fold improvements in potency at cdk5 and 12-fold selectivity over cdk2 were achieved. In the experimental materials used by the author, we found 5-Bromothiazol-2-amine(cas: 3034-22-8Related Products of 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Related Products of 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2013,Al-Omary, Fatmah A. M.; Hassan, Ghada S.; El-Messery, Shahenda M.; Nagi, Mahmoud N.; Habib, El-Sayed E.; El-Subbagh, Hussein I. published 《Nonclassical antifolates, part 3: Synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones》.European Journal of Medicinal Chemistry published the findings.Name: 5-Bromothiazol-2-amine The information in the text is summarized as follows:

Compounds I(R1 = Me, R2 = H, R3 = H, n = 0; R1 = R2 = MeO, R3 = H, CO2Et, n = 0) and 39 proved to be active DHFR inhibitors with IC50 range of 0.3-0.8 μM. Compounds I(R1 = Me, R2 = H, R3 = H, n = 0; R1 = R2 = MeO, R3 = H, CO2Et, n = 0) and 39 proved to be active DHFR inhibitors with IC50 range of 0.3-0.8 μM. Compounds I(R1 = R2 = MeO, R3 = H, n = 0; R1 = Me, R2 = H, R3 = CO2Et, n = 0, 1) and II(R1 = Me, R2 = H, n = 0; R1 = R2 = MeO, n = 1) showed broad spectrum antimicrobial activity comparable to the known antibiotic gentamicin. Compound II(R1 = Me, R2 = H, n = 1) showed broad spectrum antitumor activity toward several tumor cell lines with GI values range of 25.8-41.2%. Mol. modeling studies concluded that recognition with key amino acid Arg38 and Lys31 are essential for binding and biol. activities. Flexible alignment; electrostatic and hydrophobic mappings revealed that the obtained model could be useful for the development of new DHFR inhibitors. In the experiment, the researchers used many compounds, for example, 5-Bromothiazol-2-amine(cas: 3034-22-8Name: 5-Bromothiazol-2-amine)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Name: 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Computed Properties of C3H3BrN2SIn 2012 ,《Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Mattmann, Margrith E.; Yu, Haibo; Lin, Zhihong; Xu, Kaiping; Huang, Xiaofang; Long, Shunyou; Wu, Meng; McManus, Owen B.; Engers, Darren W.; Le, Uyen M.; Li, Min; Lindsley, Craig W.; Hopkins, Corey R.. The article contains the following contents:

A high-throughput screen utilizing a depolarization-triggered thallium influx through KCNQ1 channels was developed and used to screen the MLSMR collection of over 300,000 compounds An iterative medicinal chem. approach was initiated and from this effort, ML277 (I) was identified as a potent activator of KCNQ1 channels (EC50 = 260 nM). ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity vs. KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel. The experimental process involved the reaction of 5-Bromothiazol-2-amine(cas: 3034-22-8Computed Properties of C3H3BrN2S)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Computed Properties of C3H3BrN2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Recommanded Product: 5-Bromothiazol-2-amineIn 2011 ,《Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3]diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12,6]diazepine analogues》 was published in European Journal of Medicinal Chemistry. The article was written by El-Subbagh, Hussein I.; Hassan, Ghada S.; El-Azab, Adel S.; Abdel-Aziz, Alaa A.-M.; Kadi, Adnan A.; Al-Obaid, Abdulrahman M.; Al-Shabanah, Othman A.; Sayed-Ahmed, Mohamed M.. The article contains the following contents:

6,7-Dihydro-thiazolo[3,2-a][1,3]diazepines, benzo[d]thiazolo[5,2-a][12,6]diazepines and benzo[d]oxazolo[5,2-a][12,6]diazepine were synthesized and evaluated for their anticonvulsant activity. Compounds (E)-2-bromo-6,7-dihydro-thiazolo[3,2-a][1,3]diazepine-8(5H)-thione, 3-chloro-benzo[d]thiazolo[5,2-a][12,6]diazepin-10-one, and 4-chloro-benzo[d]oxazolo[5,2-a][12,6] diazepin-10-one showed 100% protection against PTZ- and bicuculline-induced seizures; 70%, 33%, 70% protection against MES-induced tonic extension; and 70%, 66%, 100% protection against picrotoxin-induced convulsions, resp. These compounds proved to act as GABAA receptor agonists, with ED50 values of 252, 380, 251 mg/kg; TD50 values of 398, 417, 355 mg/kg; PI values of 1.58, 1.09, 1.41; LD50 values of 380, 617, 537 mg/kg and TI values of 1.51, 1.62, 2.14, resp. After reading the article, we found that the author used 5-Bromothiazol-2-amine(cas: 3034-22-8Recommanded Product: 5-Bromothiazol-2-amine)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《In vitro bioaccessibility and activity of Greek oregano (Origanum vulgare L. ssp. hirtum (link) Ietswaart) compounds as affected by nitrogen fertilization》 was written by Seczyk, Lukasz; Krol, Beata; Kolodziej, Barbara. Application of 30931-67-0 And the article was included in Journal of the Science of Food and Agriculture on April 30 ,2020. The article conveys some information:

Greek oregano is a culinary and medicinal herb native to the Mediterranean region; however nowadays it is cultivated in many regions all over the world. It is commonly used as a spice for flavoring food products and in various traditional medicine applications. This study investigated the effect of nitrogen fertilization at 0-150 kg N ha-1 on the potential bioaccessibility and activity of Greek oregano compounds For this purpose the total phenolic content, rosmarinic acid content, and antioxidant activities of the raw material, as well as digested fractions, were determined Nitrogen fertilization had a neg. influence on the phenolic content and antioxidant activity of raw material; however, its effect on the potential bioaccessibility varied depending on the dose. The highest potential bioaccessibility and activity was determined for plants fertilized with 30 kg N ha-1. For the gastric and intestinal phases of digestion, the potential bioaccessibility percentages were 39.5% and 29.6% for total phenolics, 53.1% and 11.2% for rosmarinic acid content, 45.2% and 44.4% for antiradical activity against 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 39.2% and 27.2% for antiradical activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 50.2% and 23.4% for reducing power, resp. The results showed that nitrogen fertilization is an important factor determining the in vitro bioaccessibility of Greek oregano compounds Furthermore, the nutraceutical potential of herbs, in term of the bioaccessibility of bioactive compounds, may be optimized during plant cultivation by applying an accurate nitrogen level. The results came from multiple reactions, including the reaction of ABTS Diammonium(cas: 30931-67-0Application of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Application of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Regulable cross-coupling of alcohols and benzothiazoles via a noble-metal-free photocatalyst under visible light》 was written by Pan, Zi-Tong; Qi, Xu-Kuan; Xiao, Qian; Liang, Xi-Wen; Zhong, Jian-Ji; Jian, Jing-Xin; Tong, Qing-Xiao. Recommanded Product: 95-24-9 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022. The article conveys some information:

Two series of alkyl-derived benzothiazoles I [R = Et, iPr, cyclohexyl, etc.; R1 = H, 4-Cl, 7-Br, etc.] and acetyl-derived benzothiazoles II [R2 = Me, Et, n-Bu, etc.; R3 = H, 4-Cl, 6-Br, etc.] were synthesized via noble-metal-free photocatalyzed regulable cross-coupling reaction of benzothiazoles and alcs. with the highest isolated yields of up to 99% and 90% resp. In the experimental materials used by the author, we found 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Recommanded Product: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Recommanded Product: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Adsorption of caffeic acid on chitosan powder》 was written by Liudvinaviciute, Dovile; Rutkaite, Ramune; Bendoraitiene, Joana; Klimaviciute, Rima; Zambzickaite, Greta. Application of 30931-67-0 And the article was included in Polymer Bulletin (Heidelberg, Germany) on April 30 ,2021. The article conveys some information:

Abstract: Adsorption of caffeic acid (CA) on chitosan (CH) powder from aqueous solution has been investigated to obtain insoluble CA-CH complex powders having different amount of CA. The pseudo-second kinetic model and the Langmuir, Freundlich and Dubinin-Radushkevich adsorption models were used to describe the kinetic and equilibrium adsorption of CA on CH. With the increase of adsorption temperature, the rate of adsorption increased while the amount of adsorbed CA decreased. The Langmuir adsorption model predicted that adsorption of CA takes place on the ionized amino groups of CH. However, with the increase of adsorption temperature the ion-exchange between carboxylic groups of CA and amino groups of CH became moderately difficult. The thermodn. characteristics of adsorption have been evaluated. CA-CH complex formation was confirmed by FT-IR spectroscopy. With increasing amount of adsorbed CA the CA-CH powder was becoming more hydrophobic. 2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) assay confirmed that CA retained the antioxidant activity when immobilized on chitosan power. In the experiment, the researchers used ABTS Diammonium(cas: 30931-67-0Application of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica