Day: October 13, 2022

Khiat, Manel; Zradni, Fatima-Zohra; Kasmi-Mir, Souad; Baeza, Alejandro published the artcile< Study of the electrochemical behavior of merocyanine and merocarbocyanine salts and their transformation into π-electron donor molecules, namely tetrathiatetraazafulvalenes>, Computed Properties of 10574-69-3, the main research area is tetrathiatetraazafulvalene electrochem preparation cyclic voltammetry voltammogram.

An electrochem. study using cyclic voltammetry method was carried out on some previously prepared merocyanines salts, namely thiazolideniumsulfonate salts and thiazolidenium chloride salts I [R = Ph, Bn; R1 = H, SMe; X = Cl, 4-methylbenzenesulfonate] and merocarbocyanines salts, namely alkylidenthiazolidenium sulfonate salt and alkylidenthiazolidenium chloride salt II [R = n-Pr]. These salts were transformed by dimerization in situ in a voltammetric cell into tetrathiatetraazafulvalenes (TTTAFs) such as III supposed to be π-electron donor mols. due to existing conjugation in their structure. The structure of all new chem. synthesized mols. was confirmed by IR, 1H-NMR, 13C-NMR, and MS. The transformation of salts into TTTAF was confirmed by a reversible voltammogram curve and variation of observed potentials.

Indonesian Journal of Chemistry published new progress about Charge transfer complexes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Computed Properties of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shah, Mayuri Nilesh; Joshi, Vidya published the artcile< Synthesis of substituted N-(3,5-dimethoxyphenyl/ styryl)-N1-(thiazol-2-yl)ureas>, SDS of cas: 57493-24-0, the main research area is thiazolylurea styryl dimethoxyphenyl; urea thiazolyl.

4-Substituted 2-aminothiazoles, obtained by condensation of substituted ω-bromoacetoketones with thiourea, on reaction with 3,5-dimethoxyphenyl isocyanate gave new N-(3,5-dimethoxyphenyl)-N1-(4-substituted thiazol-2-yl)ureas, e.g. I. Similarly, the 4-substituted 2-aminothiazoles on treatment with styryl isocyanate gave N-styryl-N1-(4-substituted thiazol-2-yl)ureas, e.g. II.

Indian Journal of Heterocyclic Chemistry published new progress about 57493-24-0. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Condon, F. E.; Shapiro, D.; Sulewski, P.; Vasi, I.; Waldman, R. published the artcile< Facile and uniform procedure for the large-scale preparation of some N-alkylrhodanines>, Synthetic Route of 10574-69-3, the main research area is rhodanine alkyl; chloroacetic acid thiocarbamate cyclization.

3-Methyl-, ethyl-, allyl-, and benzylrhodanine were prepared by treating the appropriate primary amine with CS2 in the presence of NH3 and the resulting ammonium alkyldithiocarbamate with ClCH2CO2H.

Organic Preparations and Procedures International published new progress about 10574-69-3. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Synthetic Route of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Mu-Xuan; Qin, Hong-Wei; Liu, Chao; Lv, Shen-Ming; Chen, Jia-Shu; Wang, Chun-Gu; Chen, Ying-Ying; Wang, Jia-Wei; Sun, Jin-Yue; Liao, Zhi-Xin published the artcile< Synthesis and biological evaluation of thiazolidine-2-thione derivatives as novel xanthine oxidase inhibitors>, Synthetic Route of 96-53-7, the main research area is thiazolidine thione preparation xanthine oxidase inhibitor SAR mol modeling.

In this study, a series of novel thiazolidine-2-thione derivatives I (R1 = Et, Pr, Ph, benzyl) and II (R2 = Et, 3-pyridyl, cyclohexyl, etc.) were synthesized as XO inhibitors, and the XO inhibitory potencies of obtained compounds I and II was evaluated by in vitro enzyme catalysis. The result shown that compound II [R2 = (4-fluorobenzene)sulfonyl] behaved the strongest XO inhibitory activity with an IC50 value of 3.56μmol/L, which was approx. 2.5-fold more potent than allopurinol. The structure-activity relationship revealed that the phenyl-sulfonamide group was indispensable for thiazolidine-2-thione derivatives II [R2 = (4-fluorobenzene)sulfonyl] to produce XO inhibitory activity. The enzyme inhibition kinetics analyses confirmed that compound II [R2 = (4-fluorobenzene)sulfonyl] exerted a mixed-type XO inhibition. Addnl., the mol. docking results suggested that the 4-fluorophenyl-sulfonyl moiety could interact with Gly260 and Ile264 in the innermost part of the active pocket through 2 hydrogen bonds, while the thiazolidinethione moiety could form two hydrogen bonds with Glu263 and Ser347 in hydrophobic pockets. In summary, the results described above suggested that compound II [R2 = (4-fluorobenzene)sulfonyl] could be a valuable lead compound for the treatment of hyperuricemia as a novel XO inhibitor.

PLoS One published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Synthetic Route of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Galan, Elena; Andreu, Raquel; Garin, Javier; Mosteo, Laura; Orduna, Jesus; Villacampa, Belen; Diosdado, Beatriz E. published the artcile< Influence of thiazole regioisomerism on second-order nonlinear optical chromophores>, Safety of Thiazole-5-carboxyaldehyde, the main research area is effect thiazole regioisomerism second order nonlinear optical chromophore.

Two series of matched and mismatched donor-thiazole-acceptor chromophores have been synthesized to disclose the role that the orientation of the thiazole ring plays on their second-order nonlinear optical (NLO) properties. Whereas previous theor. studies predict that the matched systems show markedly higher NLO responses, our exptl. results do not parallel this trend, showing differences between regioisomers much lower than those predicted.

Tetrahedron published new progress about Bond length. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Safety of Thiazole-5-carboxyaldehyde.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vydzhak, R. N.; Brovarets, V. S.; Pil’o, S. G.; Drach, B. S. published the artcile< Synthesis and Transformations of Two Types of 4-Phosphorylated Aldehydes of the Oxazole Series>, Name: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is formylpiperidinyloxazolyl phosphonate preparation; formyloxazolyl phosphonate preparation; piperidinyl formyloxazolyl phosphonate preparation; morpholinyl formyloxazolyl phosphonate preparation; phosphonium oxothiazolylideneoxazolyl preparation; thiazolylhydrazonooxazolyl phosphonate preparation.

The reaction of 2,2-dichloro-N-(1,2,2,2-tetrachloroethyl)acetamide with trialkyl phosphites and triphenylphosphine gave [2,2-dichloro-1-[(dichloroacetyl)amino]ethenyl]triphenylphosphonium chloride and [2,2,2-trichloro-1-(dichloroacetyl)amino]phosphonic acid di-Me ester and [2,2,2-trichloro-1-(dichloroacetyl)amino]phosphonic acid di-Et ester. Cyclocondensation of the latter in the presence of amines gave [2-formyl-5-(1-piperidinyl)-4-oxazolyl]phosphonic acid di-Me ester (I), [2-formyl-5-(1-piperidinyl)-4-oxazolyl]phosphonic acid di-Et ester (II) and [2-formyl-5-(4-morpholinyl)-4-oxazolyl]phosphonic acid di-Me ester (III) and [2-formyl-5-(4-morpholinyl)-4-oxazolyl]phosphonic acid di-Et ester (IV). Their structure of products was determined by spectroscopy and also by chem. transformations into phenylhydrazones, thiosemicarbazones, aminals, and other functional derivatives of I-IV.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about Condensation reaction. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Name: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Din Reshi, Noor U.; Senthurpandi, Dineshchakravarthy; Samuelson, Ashoka G. published the artcile< Asymmetric transfer hydrogenation of ketones using Ru(0) nanoparticles modified by Chiral Thiones>, Electric Literature of 171877-39-7, the main research area is ketone asym transfer hydrogenation; oxazolidinethione thiozolidinethione ruthenium half sandwich complex catalyst preparation.

The catalytic asym. transfer hydrogenation (ATH) of acetophenone in isopropanol by Ru(0) nanoparticles (NPs) obtained by the in-situ reduction of Ru(II) half-sandwich complexes of chiral 2-oxazolidinethiones and 2-thiozolidinethiones was examined and compared with the catalytic activity of Ru(0) NPs formed in-situ by the reduction of [Ru(p-cymene)(Cl)2]2 in presence of optically active ligands such as (S)-4-isobutylthiazolidine-2-thione, (S)-4-isopropyl-2(-2-pyridinyl)-2-oxazoline, (8S, 9R)-(-)-cinchonidine, (S)-leucinol, (S)-phenylalaninol, and (S)-leucine. Three of the best catalytic systems were then examined for ATH of thirteen aromatic ketones with different electronic and steric properties. A maximum of 24% ee was obtained using NPs generated from the Ru (II) half-sandwich complex with (S)-4-isobutylthiazolidine-2-thione in the TH of acetophenone. The NPs were characterized by TEM and DLS measurements. Kinetic studies and poisoning experiments confirmed that the reaction is catalyzed by the chiral NPs formed in-situ. Complete characterization of the complexes, including the X-ray crystallog. characterization of two complexes, was also carried out.

Applied Organometallic Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Electric Literature of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vafina, G. F.; Guryanova, T. S. published the artcile< Synthesis of S-Containing Maleopimaric Acid Derivatives>, Related Products of 96-53-7, the main research area is maleopimaric acid thio analog preparation.

New S-containing maleopimaric acid derivatives were synthesized. The structures of all synthesized compounds were elucidated using NMR spectroscopy and elemental analyses.

Chemistry of Natural Compounds published new progress about Diterpenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Related Products of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Marwaha, Tejinder Kaur; Madgulkar, Ashwini; Bhalekar, Mangesh; Asgaonkar, Kalyani published the artcile< Molecular docking, synthesis, and characterization of chitosan-graft-2-mercaptobenzoic acid derivative as potential drug carrier>, COA of Formula: C3H5NS2, the main research area is docking chitosan mercaptobenzoic acid derivative drug carrier.

Chitosan is a hydrophilic polymer with prominent mucoadhesive properties. However, it forms weak hydrogen bonds with mucin thus limiting its mucoadhesion and exhibit reduced bioavailability due to its short retention time in the body. The aim of the present study was to synthesize and characterize novel thiolated chitosan with improved functional property. A unique approach of using mol. docking to select ligand to chem. modify chitosan has been employed in the present research. A set of ligands were screened virtually using docking anal. and 2-mercapto benzoic acid showed the lowest glide score of -4.31 Kcal/Mol thus displayed better binding interaction with chitosan. Based on the docking results, the best-fit ligand was selected for wet laboratory synthesis. 2-Mercapto benzoic acid was covalently attached to chitosan via formation of an amide bond and the reaction was mediated by carbodiimide and N-hydroxysuccinimide. The synthesized polymer was in turn evaluated for zeta potential, Fourier transformed IR, differential scanning calorimetry, mol. weight that confirmed conjugation of chitosan with the thiol ligand. The prepared thiomer was further subjected to mucoadhesion studies and displayed better mucoadhesion properties as compared to unmodified chitosan. Thus, the potential of the novel thiomer can be further explored as an excipient for drug delivery system with an emphasis on mucoadhesion.

Journal of Applied Polymer Science published new progress about Differential scanning calorimetry. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, COA of Formula: C3H5NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kamble, Sonali S.; Hese, Shrikant V.; Dawane, Bhaskar S.; Gacche, Rajesh N. published the artcile< Anti-breast cancer and antiangiogenic potential of substituted thiazolo[2,3-b] quinazoline derivatives: synthesis, in vitro and in vivo analysis>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is thiazolo quinazoline derivative antibreast cancer antiangiogenic potential.

Herein, a series of novel substituted thiazolo[2,3-b]quinazoline derivatives has been synthesized. The capability of the synthesized compounds 3a-i to hinder the viability of human breast cancer cell line (MCF-7) was assessed. The compounds were evaluated as possible inhibitors of angiogenesis by using in vivo chorioallantoic membrane (CAM) model. Amongst the compounds 3a-i screened, 3d and 3f exhibited excellent cytotoxicity with IC50 values 6.0±0.03μM & 5.0±0.36μM resp. Compounds were further tested to evaluate potential to inhibit the pro-angiogenic cytokines associated with tumor development. Both the compounds were found to be potent antiangiogenic agents against VEGF, TNFa, IL6, TGFb, and EGF. The outcome of the present study reveals that, compound 3d and 3f showed the promising inhibitory activity on the viability of MCF-7 cells. In the in vivo CAM model, treatment with all the compounds resulted in the significant decrease in blood vessels d. The findings of the study suggest that, compounds 3d & 3f may act as potential anti-breast cancer and antiangiogenic agents.

Chemistry & Biology Interface published new progress about Angiogenesis. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica