Day: October 13, 2022

The author of 《Synthesis, characterization and anthelmintic screening of some new benzothiophene derivatives》 were Kallur, H. J.; Mathapati, Prabhudev S.; C., Kishore Singh; Malpani, Ashok. And the article was published in World Journal of Pharmaceutical Research in 2020. Application of 95-24-9 The author mentioned the following in the article:

The proposed work was carried out by following Schemes. In the Scheme-I the starting material cinnamic acid was reacted with thionyl chloride, in presence of pyridine in chlorobenzene medium to yield 3- chlorobenzo[b]thiophene-2-carbonylchloride. Where as in the Scheme-II the 2-amino-6-substituted benzothiazoles I (R = Me, COOEt, Cl, OMe, F, nitro) was prepared by the reaction of 4-substituted anilines 4-RC6H4NH2 and potassium thiocyanate in presence of bromine in acetic acid. In the scheme-III, the compound N-(6-substituted-1,3-benzothiazol-2-yl)-3-chloro-1-benzothiophene-2-carboxamides II was prepared by reacting 3-chlorobenzo[b]thiophene-2-carbonylchloride and 2-amino-6-substituted benzothiazoles I in pyridine medium refluxed for 10-15 h. The synthesized compounds II were evaluated for the anthelmintic activity. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Application of 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application of 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2001,Kitagawa, Tokujiro; Akiyama, Naohiro; Masai, Katsunori published 《Preparation and root growth-modulatory activity of N-substituted 2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanamides》.Chemical & Pharmaceutical Bulletin published the findings.Category: thiazole The information in the text is summarized as follows:

N-Substituted 2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanamides were synthesized through the reaction of amines with 2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanoic acid, which was prepared via condensation of 2-(bromomethyl)furan with di-Et acetamidomalonate, followed by partial hydrolysis of the resultant di-Et ester in the presence of barium hydroxide. However, bulky amines such as tert-butylamine or 2-trifluoromethylaniline did not afford the corresponding diamides. The biol. activity of the prepared diamides as root growth modulators was examined by germination assay using rape and leek seeds. N-(5-Bromo-2-thiazolyl)- and N-(4-chloro-2-benzothiazolyl)-2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanamides both potently inhibited the root growth of rape seedlings, but were less effective in the case of leek seeds. The herbicide 2,4-dichlorophenoxyacetic acid completely inhibited root growth in both cases. The results came from multiple reactions, including the reaction of 5-Bromothiazol-2-amine(cas: 3034-22-8Category: thiazole)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2003,Razus, Alexandru C.; Birzan, Liviu; Nae, Stefania; Surugiu, Mirela Nina; Cimpeanu, Valentin published 《Azulene-1-azo-2′-thiazoles. Synthesis and properties》.Journal of Heterocyclic Chemistry published the findings.Reference of 5-Bromothiazol-2-amine The information in the text is summarized as follows:

Several derivatives belonging to a new compound class, namely azulene-1-azo-2′-thiazoles, were prepared by the diazotization of 2-aminothiazoles in the presence of HNO3/H3PO4 followed by the coupling of diazonium salts with azulenes in buffered medium. The reactions proved to be general for this class, with the yields being considerably influenced by the thiazole substituents. For the first time a N-oxide of an amino-substituted five-membered nitrogen heterocycle was diazotized and coupled. The structure of the obtained azo dyes was assigned and their physico-chem. properties were discussed. The new azulene azo derivatives exhibit a strong bathochromic shift in their UV-visible spectra due to the intense push-pull effect of the azulene aromatic system and the intrinsic properties of the thiazole moiety. In the part of experimental materials, we found many familiar compounds, such as 5-Bromothiazol-2-amine(cas: 3034-22-8Reference of 5-Bromothiazol-2-amine)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Reference of 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2005,Kitagawa, Tokujiro; Asada, Makoto published 《Preparation and root growth-inhibitory activity of N-substituted 2-(2-chloroacetamido)-3-(furan-2-yl)propanamides》.Chemical & Pharmaceutical Bulletin published the findings.HPLC of Formula: 3034-22-8 The information in the text is summarized as follows:

A series of N-substituted 2-(2-chloroacetamido)-3-(furan-2-yl)propanamides, e.g., I, was prepared through the reaction of chloroacetyl chloride with N-substituted 2-amino-3-(furan-2-yl)propanamides, which were obtained by condensation of 2-(tert-butoxycarbonylamido)-3-(furan-2-yl)propanoic acid (Boc-furylalanine) with amines, followed by hydrolysis of the resultant N-substituted Boc-furylalanine acid amides in the presence of HCl/dioxane. The biol. activity of the prepared compounds as root growth inhibitors was examined by germination assay using rape seed. At the concentration of 5.0 × 10-5 M, the most active compound, 2-(2-chloroacetamido)-N-(2,6-diethylphenyl)-3-(furan-2-yl)propanamide (I), showed potent root growth-inhibitory activity of 76% towards rape seedlings. After reading the article, we found that the author used 5-Bromothiazol-2-amine(cas: 3034-22-8HPLC of Formula: 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.HPLC of Formula: 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2014,Li, Ningning; Xu, Yintong; Xia, Qiang; Bai, Cuigai; Wang, Taiyi; Wang, Lei; He, Dingdi; Xie, Nannan; Li, Lixin; Wang, Jing; Zhou, Hong-Gang; Xu, Feng; Yang, Cheng; Zhang, Quan; Yin, Zheng; Guo, Yu; Chen, Yue published 《Simplified captopril analogues as NDM-1 inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Synthetic Route of C3H3BrN2S The information in the text is summarized as follows:

Captopril is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 value of 7.9 μM. It is composed of two units: a 3-mercapto-2-methylpropanoyl fragment and a proline residue. In this study, the authors synthesized simple amide derivatives of 3-mercapto-2-methylpropanoic acid, and then tested them as NDM-1 inhibitors to identify the pharmacophore for NDM-1 inhibition. The authors found that the lead compound(R)-N-benzyl-3-mercapto-2-methylpropanamide had an IC50 value of 1.0 μM. Further structure simplification provided compounds 3-mercapto-2-methylpropan-1-ol and 2,3-dimercaptopropan-1-ol, which had IC50 values of 15 and 10 μM, resp. As 2,3-dimercaptopropan-1-ol is a clin. used antidote for metal poisoning, it has great potential to be repurposed to treat bacterial infections.5-Bromothiazol-2-amine(cas: 3034-22-8Synthetic Route of C3H3BrN2S) was used in this study.

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Synthetic Route of C3H3BrN2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Synthesis of Imidazo[1,2-a]pyridines and Imidazo[2,1-b]thiazoles Attached to a Cycloalkyl or Saturated Heterocycle Containing a Tertiary Hydroxy Substitution》 were Chenna Reddy, M. L.; Patil, Vineetkumar B.; Nawaz Khan, Fazlur Rahman; Saravanan, Vadivelu. And the article was published in Journal of Heterocyclic Chemistry in 2019. Application of 3034-22-8 The author mentioned the following in the article:

A new method has been developed for the synthesis of imidazo[1,2-a]pyridines I (R = H, Me, CN, Br, OMe, etc.; R1 = R2 = H; R1R2 = CH=CH-CH=CH; RR1 = CH=CH-CH=CH; X = CH2, O, S; n = 0, 1, 2), imidazo[2,1-b]thiazoles II (R3 = H, Me, Br, Cl, COOMe; X = CH2, O, S; n = 0, 1, 2), and benzo[d]imidazo[2,1-b]thiazoles III (R4 = H, OMe, Br, F, CF3) attached to a cycloalkyl or saturated heterocycle containing a tertiary hydroxy substitution. Readily available substituted 2-aminopyridines, 2-aminothiazoles, and 2-aminobenzothiazoles were treated with bromohydroxycycloalkyl ethanones IV to afford the desired products in good yields. In the experiment, the researchers used 5-Bromothiazol-2-amine(cas: 3034-22-8Application of 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Application of 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Phytochemical profile and comparative anti-radical scavenging activities of n-hexane extracts of indigenous Zingiber officinale and Curcuma longa》 was written by Nweze, Chibuzo Carole; Dingwoke, Emeka John; Adamude, Fatima Amin; Nwobodo, Nwobodo Ndubuisi. Synthetic Route of C18H24N6O6S4 And the article was included in Free Radicals and Antioxidants in 2019. The article conveys some information:

Objectives: Free radical scavenging activities of n-haxane extracts of indigenous Curcuma longa and Zingiber officinale was investigated and compared to CellGevity; a nutraceutical antioxidant supplement. Methods: We used 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, 2,2′-Azino-bis3-ethylbenzothialine-6-sulfonic acid (ABTS) radical cations and hydrogen peroxide (H2O2) to determine free radical scavenging activities of the extracts The ability of the extracts to scavenge free radicals was determined following the discoloration of the solution mixtures, measured spectrophotometrically. The reducing power efficacy of the extracts was determined by their ability to reduce Fe3+ to Fe2+ ions. Results:Curcuma longa and Zingiber officinale have more free radical scavenging power compared to CellGevity. Curcuma longa has more scavenging power against DPPH and H2O2 system, while Zingiber officinale has more scavenging power against ABTS cations. CellGevity had the least scavenging activity against the free radicals, as observed in this study. The highest phenolic, flavonoid, Vitamin C, Vitamin B1 and Vitamin B2 quantified were found in Curcuma longa and Zingiber officinale compared to CellGevity. Conclusion: The indigenous Curcuma longa and Zingiber officinale are natural sources of effective antioxidants with more scavenging power compared to a standard CellGevity nutraceutical. In the part of experimental materials, we found many familiar compounds, such as ABTS Diammonium(cas: 30931-67-0Synthetic Route of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Synthetic Route of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Poly (urethane-urea)-epoxy glass fiber reinforced composites》 were Joshi, Medha; Desai, Dhaval; Jauhari, Smita. And the article was published in International Journal of ChemTech Research in 2021. HPLC of Formula: 95-24-9 The author mentioned the following in the article:

A series of poly(urethane-urea)s (PUU)s were synthesized using toluene 2, 4- diisocyanate, various 2-amino benzothiazoles and 3-amino phenol. All the PUUs were characterized by elemental anal., spectral studies, number average mol. weight (Mn) and thermogravimetry. Further reaction of PUUs was carried out with an epoxy resin (i.e.DGEBA). The curing study of prepared resins was monitored by DSC. Based on DSC thermograms glass fiber reinforced composites have been laminated and characterized by chem., mech. and elec. properties. The unreinforced cured resins were subjected to thermogravimetric anal. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica