Takeda, Norihiko; Taguchi, Tomoyo; Nakajima, Takeshi; Azuma, Mitsuyoshi published the artcile< Design, synthesis and biological activity evaluation of thiazolidinones containing alkynyl and alkenyl furans for disrupting protein-protein interactions between HIF-1α and p300>, Reference of 10574-69-3, the main research area is thiazolidinone furanylidene preparation HIF1alpha p300 interaction inhibitor.
Based on the structure of the potent hypoxia-inducible factor (HIF) inhibitor, a novel series of furanylidene thiazolidinones I (R1 = trimethylsilylethynyl, triethylsilylethynyl, cyclopropylethynyl, etc.; R2 = C6H5,CH2NMe2, CH2C6H5, etc.) were designed and synthesized using Sonogashira or Suzuki-Miyaura cross-couplings, and subsequent Knoevenagel condensation. In particular, derivatives I (R1 = trimethylsilylethynyl, t-butylethynyl, cyclopropylethynyl, t-butylethenyl, cyclopropylethenyl; R2 = C6H5,CH2(4-methylpiperazin-1-yl)) bearing an alkynyl or alkenyl group on the furan ring, exhibited four- to five-fold higher activities than II. These potent compounds will serve as leads for the development of novel small mols. for targeting the HIF-1α/p300 complex.
Heterocycles published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Reference of 10574-69-3.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica