In 2009,Uto, Yoshikazu; Ogata, Tsuneaki; Kiyotsuka, Yohei; Miyazawa, Yuriko; Ueno, Yuko; Kurata, Hitoshi; Deguchi, Tsuneo; Yamada, Makiko; Watanabe, Nobuaki; Takagi, Toshiyuki; Wakimoto, Satoko; Okuyama, Ryo; Konishi, Masahiro; Kurikawa, Nobuya; Kono, Keita; Osumi, Jun published 《Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation》.Bioorganic & Medicinal Chemistry Letters published the findings.Application of 3034-22-8 The information in the text is summarized as follows:
The continuing investigation of SAR studies of 3-(2-hydroxyethoxy)-N-(5-benzylthiazol-2-yl)benzamides as stearoyl-CoA desaturase-1 (SCD-1) inhibitors was reported. A prior hit-to-lead effort resulted in the identification of I (R = OMe) as a potent and orally efficacious SCD-1 inhibitor. Further optimization of the structural motif resulted in the identification of I (R = NHEt) with sub-nanomolar IC50 in both murine and human SCD-1 inhibitory assays. This compound demonstrated a dose-dependent decrease in the plasma desaturation index in C57BL/6J mice on a non-fat diet after 7 days of oral administration. In addition to this study using 5-Bromothiazol-2-amine, there are many other studies that have used 5-Bromothiazol-2-amine(cas: 3034-22-8Application of 3034-22-8) was used in this study.
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 3034-22-8
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica