Aihara, Kazuhiro; Kano, Yuko; Shiokawa, Sohjiro; Sasaki, Toshiro; Setsu, Fumihito; Sambongi, Yumiko; Ishii, Miyuki; Tohyama, Kazuyo; Ida, Takashi; Tamura, Atsushi; Atsumi, Kunio; Iwamatsu, Katsuyoshi published the artcile< CP0569, A New Broad-Spectrum Injectable Carbapenem. Part 1: Synthesis and Structure-Activity Relationships>, Safety of Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate, the main research area is methylcarbapenem antimicrobial activity.
A series of 1β-methylcarbapenems bearing an (imidazo[5,1-b]thiazolium-6-yl)methyl moiety, a 5,5-fused heterobicycle, at the C-2 position was synthesized and evaluated for in vitro antibacterial activities. CP0569 (1r) and its analogs showed potent antibacterial activities against Gram-pos. bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Gram-neg. bacteria, including Pseudomonas aeruginosa. Moreover, CP0569 (1r) exhibited stronger antibacterial activity against MRSA and higher resistance to renal dehydropeptidase-1 (DHP-1) than any currently marketed carbapenems, i.e., imipenem (IPM), panipenem (PAPM), and meropenem (MEPM).
Bioorganic & Medicinal Chemistry published new progress about Antimicrobial agents. 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Safety of Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica