Bazhin, Arkadiy A.; Sinisi, Riccardo; De Marchi, Umberto; Hermant, Aurelie; Sambiagio, Nicolas; Maric, Tamara; Budin, Ghyslain; Goun, Elena A. published the artcile< A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential>, Reference of 2591-17-5, the main research area is bioluminescent probe mitochondria membrane potential.
Mitochondrial membrane potential (ΔΨm) is a universal selective indicator of mitochondrial function and is known to play a central role in many human pathologies, such as diabetes mellitus, cancer and Alzheimer′s and Parkinson′s diseases. Here, the authors report the design, synthesis and several applications of mitochondria-activatable luciferin (MAL), a bioluminescent probe sensitive to ΔΨm, and partially to plasma membrane potential (ΔΨp), for non-invasive, longitudinal monitoring of ΔΨm in vitro and in vivo. The authors applied this new technol. to evaluate the aging-related change of ΔΨm in mice and showed that nicotinamide riboside (NR) reverts aging-related mitochondrial depolarization, revealing another important aspect of the mechanism of action of this potent biomol. In addition, the authors demonstrated application of the MAL probe for studies of brown adipose tissue (BAT) activation and non-invasive in vivo assessment of ΔΨm in animal cancer models, opening exciting opportunities for understanding the underlying mechanisms and for discovery of effective treatments for many human pathologies.
Nature Chemical Biology published new progress about Aging, animal. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Reference of 2591-17-5.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica