Murty, Surya; Haile, Samuel T.; Beinat, Corinne; Aalipour, Amin; Alam, Israt S.; Murty, Tara; Shaffer, Travis M.; Patel, Chirag B.; Graves, Edward E.; Mackall, Crystal L.; Gambhir, Sanjiv S. published the artcile< Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma model>, HPLC of Formula: 2591-17-5, the main research area is disialoganglioside GD2 CAR T cell apoptosis glioblastoma; Chimeric antigen receptor (CAR); glioblastoma; imaging; immunotherapy; intravital microscopy.
Recent advances in novel immune strategies, particularly chimeric antigen receptor (CAR)-bearing T-cells, have shown limited efficacy against glioblastoma (GBM) in clin. trials. We currently have an incomplete understanding of how these emerging therapies integrate with the current standard of care, specifically radiation therapy (RT). Addnitionally, there is an insufficient number of preclin. studies monitoring these therapies with high spatiotemporal resolution To address these limitations, we report the first longitudinal fluorescence-based intravital microscopy imaging of CAR T-cells within an orthotopic GBM preclin. model to illustrate the necessity of RT for complete therapeutic response. Complete antitumor response in advanced syngeneic orthotopic models of GBM was achieved only when a single i.v. dose of GD2 CAR T-cells was following either sub-lethal whole-body irradiation or focal RT. Intravital microscopy imaging successfully visualized CAR T-cell homing and T-cell mediated apoptosis of tumor cells in real-time within the tumor stroma. Findings indicate that RT allows for rapid CAR T-cell extravasation from the vasculature and expansion within the tumor microenvironment. These exciting results highlight potential opportunities to improve IV adoptive T-cell administration in the treatment of GBM through concurrent RT. Addnl., they emphasize the need for advancements in immunotherapeutic homing to and extravasation through the tumor microenvironment.
OncoImmunology published new progress about Apoptosis. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, HPLC of Formula: 2591-17-5.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica