In 2004,Quelever, Gilles; Burlet, Stephane; Garino, Cedrik; Pietrancosta, Nicolas; Laras, Younes; Kraus, Jean-Louis published 《Simple Coupling Reaction between Amino Acids and Weakly Nucleophilic Heteroaromatic Amines》.Journal of Combinatorial Chemistry published the findings.HPLC of Formula: 3034-22-8 The information in the text is summarized as follows:
Solution-phase amidation of amino acid Boc-Ala-OH by substituted, weakly nucleophilic heterocyclic aromatic amines was studied in presence of coupling reagents using a parallel synthesis procedure. Coupling agents POCl3/pyridine, BOP, DCC/HOBt, and HBTU were examined for this reaction. Thus, Boc-Ala-NHAr [Ar = CH2C6H4NO2-4, CH2Ph, CH2C6H11, 4-(4-nitrophenyl)-2-thiazolyl, 5-bromo-2-thiazolyl, 2-thiazolyl, 5-nitro-2-thiazolyl] were prepared in moderate to high yields. The results showed that when bulky, weakly nucleophilic, heterocyclic aromatic amines are to be coupled, POCl3 in pyridine could be used as a coupling agent in solution-phase automated synthesis for obtaining racemization-free products in reasonable good yields. In the experiment, the researchers used many compounds, for example, 5-Bromothiazol-2-amine(cas: 3034-22-8HPLC of Formula: 3034-22-8)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 3034-22-8
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica