Roosta, Atefeh; Alizadeh, Abdolali; Rezaiyehraad, Reze; Khanpour, Mojtaba published the artcile< Efficient and Chemoselective Procedure for Conversion of Rhodanine Derivatives into 1,3-Thiazolidine-2,4-diones via 1,3-Dipolar Cycloaddition Reaction and Rearrangement Sequences>, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is thiazolidinedione preparation chemoselective; alkalinity arylidene rhodanine preparation cycloaddition rearrangement.
A chemoselective 1,3-dipolar cycloaddition reaction between 5-alkylidene- or 5-arylidene rhodanine derivatives I (R1 = n-Pr, n-Bu, allyl, Bn; R2 = Ph, COOMe, 4-chloropheny, 4-methylpheny, 4-bromopheny) and nitrile oxide generated in situ from dibromoformaldoxime to construct 1,3-thiazolidine-2,4-diones II scaffold under mild conditions was reported. This strategy exhibits a distinguished manner to afford thiazolidine derivatives II in a simple, rapid and practical route. The results proved that the reaction proceeds through an unpredictable rearrangement and no spirocyclic product is generated. The structures of the target mols. were confirmed by IR, 1H NMR, 13C NMR, mass spectra and unambiguously X-ray crystal structure anal.
ChemistrySelect published new progress about 1,3-Dipolar cycloaddition reaction (chemoselective). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica