Siegel, David J.; Anderson, Grace I.; Paul, Lauren M.; Seibert, Philipp J.; Hillesheim, Patrick C.; Sheng, Yinghong; Zeller, Matthias; Taubert, Andreas; Werner, Peter; Balischewski, Christian; Michael, Scott F.; Mirjafari, Arsalan published the artcile< Design Principles of Lipid-like Ionic Liquids for Gene Delivery>, Recommanded Product: 4,5-Dihydrothiazole-2-thiol, the main research area is ionic liquid gene delivery amphiphile lipid; DNA delivery; biomaterials; cationic lipids; gene therapy; ionic liquids; lipid-like materials; nonviral vectors.
We developed lipid-like ionic liquids, containing 2-mercaptoimidazolium and 2-mercaptothiazolinium headgroups tethered to two long saturated alkyl chains, as carriers for in vitro delivery of plasmid HEK DNA into 293T cells. We employed a combination of modular design, synthesis, X-ray anal., and computational modeling to rationalize the self-assembly and desired physicochem. and biol. properties. The results suggest that thioamide-derived ionic liquids may serve as a modular platform for lipid-mediated gene delivery. This work represents a step toward understanding the structure-function relationships of these amphiphiles with long-range ordering and offering insight into design principles for synthetic vectors based on self-assembly behavior.
ACS Applied Bio Materials published new progress about Amphiphiles. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Recommanded Product: 4,5-Dihydrothiazole-2-thiol.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica