Sieng, Bora; Maldonado, Matias Funes; Romagnoli, Carlo; Amedjkouh, Mohamed published the artcile< One-Pot Alkynylation of Azaaryl Aldehydes and Spontaneous Base-Free Rearrangement into Enone Esters: an Autoinductive Mechanism>, Formula: C4H3NOS, the main research area is unsaturated ketoester diastereoselective preparation; butyllithium methylzinc catalyst addition propiolate heteroaryl aldehyde stereoselective rearrangement; isotope labeling allenoate trapping mechanism addition rearrangement propargylic alc.
When heteroaromatic aldehydes are reacted with Et propiolate in the presence of Me2Zn or BuLi, γ-oxo-α,β-unsaturated esters were generated by spontaneous rearrangements of the intermediate propargylic alcs.; in some cases, the propargyl alcs. were formed without rearrangement. The mechanism of the rearrangement was studied using isotope labeling and trapping of a proposed allenoate intermediate; an autocatalytic mechanism is proposed.
European Journal of Organic Chemistry published new progress about Addition reaction. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Formula: C4H3NOS.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica