Uppal, Archana; Singh, Anita; Kothiyal, Preeti published the artcile< Structure-based design, synthesis and antidepressant-like activity of phenylthiazolyl-1H,2H,3H,4H-naphthalene derivatives>, Related Products of 57493-24-0, the main research area is aryl thiazolyl amino tetrahydronaphthalene preparation mol docking antidepressant.
A series of new [aryl(thiazolyl)]aminotetrahydronaphthalene derivatives I [R1 = H, OMe, Cl; R2 = H, Me; R3 = 4-CH3, 3,4-di-Cl, 4-Br, etc.] were synthesized and studied for their mol. docking properties via in silico assay in CHARMm-based CDocker program. Results indicated that these compounds showed interactions towards serotonin transporters. All the titled compounds were evaluated for antidepressant activity by forced-swimming test, tail suspention test and open-field test on albino mice and acute toxicity of compounds I [R1 = OMe; R2 = H; R3 = 4-NHC(O)CH3, 3-NO2] were also studied. Antidepressant-like effect in mice tests revealed that the most active compounds were I [R1 = OMe; R2 = H; R3 = 4-NHC(O)CH3, 3-NO2] with no any toxicity.
Asian Journal of Chemistry published new progress about Antidepressants. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Related Products of 57493-24-0.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica