Application of 3034-22-8In 2017 ,《In vitro studies on the inhibition of colon cancer by amino acid derivatives of bromothiazole》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Vale, Nuno; Correia-Branco, Ana; Patricio, Barbara; Duarte, Diana; Martel, Fatima. The article contains the following contents:
The investment in cancer research is critical to find more and better treatments, but essentially to save lives. This paper describes the synthesis and characterization of bromothiazole derivatives with amino acids, e.g., I, and with core of nitazoxanide, an FDA-approved antiprotozoal drug. Using a human adenocarcinoma-derived cell line (the Caco-2 cell line), the antiproliferative (3H-thymidine incorporation) and cytotoxic (extracellular lactate dehydrogenase activity) effect of these derivatives, were investigated. All the derivatives caused a concentration-dependent decrease in cell proliferation and viability. At their highest concentration, all compounds were able to reduce 3H-thymidine incorporation by more than 80%, corresponding to a more marked antiproliferative effect than butyrate. As to their cytotoxic effect, it was comparable to that of butyrate. The ability of bromo substituent in thiazole ring with sequences of amino acids in inducing cell death and apoptosis in Caco-2 cells (and other cell lines) is now being studied. The experimental part of the paper was very detailed, including the reaction process of 5-Bromothiazol-2-amine(cas: 3034-22-8Application of 3034-22-8)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Application of 3034-22-8
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica