Wang, Ji-Quan; Pollok, Karen E.; Cai, Shanbao; Stantz, Keith M.; Hutchins, Gary D.; Zheng, Qi-Huang published the artcile< PET imaging and optical imaging with D-luciferin [11C]methyl ester and D-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice>, Computed Properties of 115144-35-9, the main research area is luciferin carbon 11 methylester methylether PET luciferase gene tumor; optical imaging luciferase gene expression tumor.
New carbon-11 labeled -luciferin analogs -luciferin [11C]methyl ester ([11C]LMEster, [11C]1) and -luciferin [11C]methyl ether ([11C]LMEther, [11C]2) were synthesized in 25-55% radiochem. yield. PET studies with [11C]LMEster and [11C]LMEther demonstrate a lower retention of the C-11 label at 45 min post-injection in luciferase expression tumor. Optical imaging with unlabeled substrate -luciferin and radiotracers [11C]LMEster and [11C]LMEther gave tumor luciferase images within a few minutes of photon counting.
Bioorganic & Medicinal Chemistry Letters published new progress about Animal gene, luc Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 115144-35-9 belongs to class thiazole, and the molecular formula is C11H7KN2O3S2, Computed Properties of 115144-35-9.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica