Zaveri, Mehul; Kawathekar, Neha published the artcile< Synthesis, characterization and antimalarial activity of some new 3-benzyl-2-thioxothiazolidin-4-one derivatives>, Category: thiazole, the main research area is benzyl thioxothiazolidinone preparation antimalarial.
In present investigation, a series of new 3-benzyl-2-thioxothiazolidin-4-one I (Ar = Ph, 2-pyrrolyl, 4-pyridyl, etc.) derivatives, have been synthesized using conventional and microwave-assisted technique. These compounds were evaluated for in-vitro antimalarial activity by microdilution technique against resistance strains of Plasmodium falciparum. The result of antimalarial activity revealed that six compounds I (Ar = Ph, 2-furanyl, 2-pyridyl, 4-pyridyl, 4-Me2NC6H4, 2-HOC6H4) exhibited IC50 values ranging from 0.8-1.2 μg/mL, four compounds I (Ar = 4-ClC6H4, 4-FC6H4, 2-indolyl, 3-O2NC6H4) displayed antimalarial activity IC50 values in the range of 0.7-0.8 μg/mL. Compound I (Ar = 2-pyrrolyl) showed most significant result with maximum IC50 value of 0.7 μg/mL, thus it could be identified as structural lead for further development of new antimalarial agents.
International Journal of Pharmacy and Pharmaceutical Research published new progress about Antimalarials. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Category: thiazole.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica