Day: October 17, 2022

Reference of ABTS DiammoniumOn November 30, 2020 ,《Ethanol extracts from Cinnamomum camphora seed kernel: Potential bioactivities as affected by alkaline hydrolysis and simulated gastrointestinal digestion》 appeared in Food Research International. The author of the article were Zhang, Guohua; Yan, Xianghui; Wu, Shasha; Ma, Maomao; Yu, Ping; Gong, Deming; Deng, Shuguang; Zeng, Zheling. The article conveys some information:

The aim of the study was to evaluate the changes of potential bioactivities of ethanol extracts (EE) from Cinnamomum camphora seed kernel (CCSK) after alk. hydrolysis and simulated gastrointestinal digestion. The total phenolic and total flavonoid contents in EE decreased by 30.6%, 1%, 33% and 11.8% after hydrolysis and digestion, resp. The total saponins content decreased by 17% after hydrolysis while increased by 48% after digestion. The total condensed tannin contents increased by 70.3% and 17.2% after hydrolysis and digestion, resp. The 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), cupric ion reducing activity (CUPRAC), ferric reducing antioxidant power (FRAP) and metal chelating activity (MCA) were used to determine antioxidant activity. Overall, the changes of antioxidant activities by hydrolysis and digestion were consistent with the changes of their total phenolic and flavonoid contents. The α-amylase and α-glucosidase inhibitory activities in EE increased by 817% and 33.3% after digestion while decreased by 12.3% and 19% after hydrolysis, resp. Although the inhibitory activities of cholinesterase, tyrosinase and xanthine oxidase were decreased by hydrolysis and digestion, most of these activities were retained. These results showed that CCSK ethanol extracts had strong bioactivities and were reasonably stable to alkali and digestive enzymes. In addition to this study using ABTS Diammonium, there are many other studies that have used ABTS Diammonium(cas: 30931-67-0Reference of ABTS Diammonium) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Reference of ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 6-Chlorobenzothiazol-2-ylamineOn October 31, 2021 ,《Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound》 appeared in Cell Death & Disease. The author of the article were Giovannucci, Tatiana A.; Salomons, Florian A.; Haraldsson, Martin; Elfman, Lotta H. M.; Wickstroem, Malin; Young, Patrick; Lundbaeck, Thomas; Eirich, Jurgen; Altun, Mikael; Jafari, Rozbeh; Gustavsson, Anna-Lena; Johnsen, John Inge; Dantuma, Nico P.. The article conveys some information:

Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery of the bioactivatable compound CBK77, which causes an irreversible collapse of the UPS, accompanied by a general accumulation of ubiquitylated proteins and caspase-dependent cell death. CBK77 caused accumulation of ubiquitin-dependent, but not ubiquitin-independent, reporter substrates of the UPS, suggesting a selective effect on ubiquitin-dependent proteolysis. In a genome-wide CRISPR interference screen, we identified the redox enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) as a critical mediator of CBK77 activity, and further demonstrated its role as the compound bioactivator. Through affinity-based proteomics, we found that CBK77 covalently interacts with ubiquitin. In vitro experiments showed that CBK77-treated ubiquitin conjugates were less susceptible to disassembly by deubiquitylating enzymes. In vivo efficacy of CBK77 was validated by reduced growth of NQO1-proficient human adenocarcinoma cells in nude mice treated with CBK77. This first-in-class NQO1-activatable UPS inhibitor suggests that it may be possible to exploit the intracellular environment in malignant cells for leveraging the impact of compounds that impair the UPS. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Reference of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Reference of 6-Chlorobenzothiazol-2-ylamineThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

B, Manjunatha; Bodke, Yadav D.; O, Nagaraja; N, Lohith T.; G, Nagaraju; Ma, Sridhar published their research in Journal of Molecular Structure on December 15 ,2021. The article was titled 《Coumarin-Benzothiazole Based Azo Dyes: Synthesis, Characterization, Computational, Photophysical and Biological Studies》.COA of Formula: C7H5ClN2S The article contains the following contents:

In this paper, we have reported the synthesis of some coumarin-benzothiazole based azo dyes (C1-C5). The structure of the synthesized dyes was precisely established from their IR, NMR and HRMS spectra. The synthesized dyes were photophys. characterized by UV-Vis and Photoluminescence studies. Through the computational study, the optimized mol. geometry, and reactive parameters were investigated to get a better insight into the mol. properties. Mol. electrostatic potential (MEP) and Reduced d. gradient (RDG) were also studied for all the compounds Diffuse reflectance study was carried out to determine the energy gap (Eg) of the synthesized dyes. Addnl., the synthesized compounds were screened for their pharmacol. property against Mycobacterium tuberculosis (H37 RV strain). The in silico mol. docking study was also performed with enoyl-ACP reductase.6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S) was used in this study.

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Li, Peng; Li, Wenqin; Xie, Zhuohao; Zhan, Haonan; Deng, Liehua; Huang, Jiahao published an article on February 28 ,2022. The article was titled 《A label-free and signal-amplifiable assay method for colorimetric detection of carcinoembryonic antigen》, and you may find the article in Biotechnology and Bioengineering.Synthetic Route of C18H24N6O6S4 The information in the text is summarized as follows:

In this work, an innovative colorimetric assay method for the determination of carcinoembryonic antigen is developed with aptamer probes utilized as recognition element. DNA hybridization chain reaction is used as signal amplification technique, and peroxidase-mimicking hemin/G-quadruplex-assisted catalytic oxidation of 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) is deployed as signal reporting mechanism. The detection principle was firstly verified by using gel electrophoresis anal. and absorbance measurements. After condition optimization, a detection limit was theor. determined as 24.8 ng/mL. Furthermore, the method exhibited good selectivity and satisfactory recovery rates (92.2%-108.6%) in serum samples. Moreover, the sensing scheme is easily extended for the detection of other analytes via similar target-aptamer recognition principle. To sum up, this is an enzyme- and label-free, cost-effective yet signal-amplifiable assay scheme for the determination of tumor markers with promising simplicity and selectivity, practical utility, and potential universality. After reading the article, we found that the author used ABTS Diammonium(cas: 30931-67-0Synthetic Route of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2019,Organic Chemistry Frontiers included an article by Zhou, Zhao-Zhao; Zhao, Jia-Hui; Gou, Xue-Ya; Chen, Xi-Meng; Liang, Yong-Min. Recommanded Product: 3034-22-8. The article was titled 《Visible-light-mediated hydrodehalogenation and Br/D exchange of inactivated aryl and alkyl halides with a palladium complex》. The information in the text is summarized as follows:

Herein, a novel photo-induced amine-free radical reductive dehalogenation of inactivated aryl/alkyl bromides and chlorides with a palladium complex is described,. Which reveals excellent functional group compatibility and broad substrate scope. Extensional transformations for reductive cyclization, dehalogenative deuteration, and intra- and intermol. radical addition can be achieved smoothly. Mechanistic studies indicate a single-electron photoredox catalytic system with inactivated solvent as the hydrogen atom donor. The experimental process involved the reaction of 5-Bromothiazol-2-amine(cas: 3034-22-8Recommanded Product: 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Recommanded Product: 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Antibacterial activity and greener method of synthesis of heterocyclic compounds incorporating benzothiazole moiety using ionic liquid as solvent》 was published in Rasayan Journal of Chemistry in 2019. These research results belong to Toshniwal, Madhu; Bundel, Mahendra; Kriplani, Prashant; Ravikant; Pareek, Rashmi; Pareek, Arun. HPLC of Formula: 95-24-9 The article mentions the following:

A novel series of substituted dimethylimidazo{2,1-b}[1,3]benzothiazoles have been synthesized by reaction of 2-amino-6-substituted benzothiazoles with halo ketone by conventional method as well as microwave conditions using ionic liquids The yield of products obtained by microwave synthesis with ionic liquids is much better than the conventional method. The reported compounds were further screened for their antibacterial activity using ampicillin as standard drug. The compounds showed excellent activity against Pseudomonas Aeruginosa, Klebsiella pneumonia and Staphylococcus aureus. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Synthesis, characteristic fragmentation patterns and antibacterial activity of new azo compounds from the coupling reaction of diazobenzothiazole ions and acetaminophen》 was published in Heterocyclic Communications in 2021. These research results belong to Tsemeugne, Joseph; Nangmo, Pamela Kemda; Mkounga, Pierre; De Dieu Tamokou, Jean; Kengne, Irene Chinda; Edwards, Giles; Sopbue, Emmanuel Fondjo; Nkengfack, Augustin Ephrem. HPLC of Formula: 95-24-9 The article mentions the following:

A series of azobenzothiazole dyes were synthesized via diazotization of substituted benzothiazole derivatives followed by azo coupling with acetaminophen. The chem. structures of all synthesized compounds were confirmed using anal. data and spectroscopic techniques, including UV-visible, IR, mass spectra and 1H- and 13C-NMR. The in situ formed diazobenzothiazole ions regiospecifically reacted with acetaminophen derivatives in the Hollemann-guided electrophilic aromatic substitution mechanism. The regio-orientations were established, on the one hand, by a rigorous interpretation of 1H-NMR spectra and, on the other hand, by the characteristic fragmentation patterns observed on the electrospray mass spectra. In the cases of I and II, multisubstitutions occurred. The antimicrobial activity of synthesized azobenzothiazole dyes, along with all the starting materials, was investigated on Pseudomonas aeruginosa PA01, Staphylococcus aureus 18, Escherichia coli 64R and S. aureus ATCC 25923. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was 1,2-bis(benzo[d]thiazol-2-yl)diazene trihydrate. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Safety of ABTS DiammoniumOn May 31, 2020, Chen, Haiqiang; Wang, Shuang; Zhou, Aimei; Miao, Jianyin; Liu, Jingyi; Benjakul, Soottawat published an article in Journal of Functional Foods. The article was 《A novel antioxidant peptide purified from defatted round scad (Decapterus maruadsi) protein hydrolysate extends lifespan in Caenorhabditis elegans》. The article mentions the following:

The residue rich in protein (up to 88.78%) obtained from round scad (Decapterus maruadsi) after oil extraction, was hydrolyzed by Alcalase to produce antioxidative peptides. The hydrolyzate was separated by ultrafiltration, Sephadex G-15 and RP-HPLC, and the active fractions were screened by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline- 6 sulfonic acid) diammonium salt (ABTS), reducing power and oxygen radical absorbance capacity (ORAC). The obtained peptide with the highest antioxidative activity was then analyzed by HPLC and LC-MS/MS and its anti-aging effect was examined using Caenorhabditis elegans (C. elegans) model. The peptide (Ile-Leu-Gly-Ala-Thr-Ile-Asp-Asn-Ser-Lys, 1153.4 Da), identified by LC-MS/MS showed the highest antioxidant activity. C. elegans fed with the selected peptide had longer lifespan, higher survival rate, superoxide dismutase (SOD) and catalase (CAT) activities than the control group (P<0.05), demonstrating the promising anti-aging effects of the antioxidant peptide from defatted round scad.ABTS Diammonium(cas: 30931-67-0Safety of ABTS Diammonium) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Safety of ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 95-24-9On March 15, 2021, Nath, Rajarshi; Shahar Yar, M.; Pathania, Shelly; Grover, Gourav; Debnath, Biplab; Akhtar, Jawaid Md published an article in Journal of Molecular Structure. The article was 《Synthesis and anticonvulsant evaluation of indoline derivatives of functionalized aryloxadiazole amine and benzothiazole acetamide》. The article mentions the following:

A series of I [R = H, 6-Cl, 5-O2N, etc.] and II [R1 = H, 4-MeO, 2-O2N, 4-O2N; R2 = H, 5-Cl, 5-Br] were designed, synthesized and fulfilled structural requirement of pharmacophore and evaluated for anticonvulsant activities using maximal electroshock test (MES), s.c. pentylenetetrazole (scPTZ) seizures and neurotoxicity by motor impairment model in mice. The most active compound I [R = 6-Cl] showed significant anticonvulsant activity against both MES and scPTZ screens and emerged as most effective anticonvulsant compound with median dose of 35.7 mg/kg (MES ED50), 88.15 mg/kg (scPTZ ED50) and toxic dose (TD50) was found to be > 500mg/kg. In-silico studies including mol. docking study were carried out to establish the mol. interaction of potent compound I [R = 6-Cl] in both Na+ channel and GABAA receptors. The prediction of pharmacokinetic parameters and distance mapping of compounds were performed to establish the drug likeness property. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Related Products of 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Related Products of 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

COA of Formula: C7H5ClN2SOn March 31, 2020, Zhang, Zhen; Gu, Ying-Lin; Wang, Zheng-Yang; Wang, Huan-Nan; Zhao, Yan; Chu, Xue-Mei; Zhang, Chun-Yan; Yan, Mao-Cai published an article in Journal of Heterocyclic Chemistry. The article was 《Synthesis and biological evaluation of novel indoleamide derivatives as antioxidative and antitumor agents》. The article mentions the following:

Novel indole amide derivatives I [R = pyrazin-2-amino, (2-methoxy-1-methyl-2-oxo-ethyl)amino, (2-oxoazepan-3-yl)amino, etc.] were successfully synthesized and characterized by 1H NMR, 13C NMR, IR, MS, and elemental anal., and their mol. formulas were C14H10N6O, C13H10N4O, C16H13N3O2, C19H14N2O2, C16H11N3OS, C15H13N3O, C12H9N5O, C16H10ClN3OS, C15H17N3O2 and C13H14N2O3, resp. The primary biol. activities of these compounds I were evaluated in-vitro by the DPPH assay, H2O2 induced oxidative stress injury assay and cytotoxicity assay. The results indicated that compounds I [R = imidazo[4,5-d]pyridazin-4-amino, pyrazin-2-amino, 7-hydroxynaphthalen-1-amino, 5H-1,2,4-triazin-4-amino, (2-oxoazepan-3-yl)amino] exhibited DPPH·scavenging ability, while I [R = 2-carbamoylanilino, 7-hydroxynaphthalen-1-amino, 1,3-benzothiazol-2-amino, 6-chloro-1,3-benzothiazol-2-amino] showed potent growth-inhibitory activities against various human tumor cells, including MDA-MB-231, Hela, A549 and HT29. Interestingly, compound I [R = 7-hydroxynaphthalen-1-amino] showed potent scavenging effects on the DPPH radical and possessed protective effect on H2O2-induced oxidative stress injury in human neuroblastoma SH-SY5Y cells at low concentrations; however, I [R = 7-hydroxynaphthalen-1-amino] exhibited significant toxicity against four human tumor cells at a higher concentration in all treatments, and the range of IC50 value was 7.91 to 13.35μM. The experimental part of the paper was very detailed, including the reaction process of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica