Bilodeau, Mark T.; Rodman, Leonard D.; McGaughey, Georgia B.; Coll, Kathleen E.; Koester, Timothy J.; Hoffman, William F.; Hungate, Randall W.; Kendall, Richard L.; McFall, Rosemary C.; Rickert, Keith W.; Rutledge, Ruth Z.; Thomas, Kenneth A. published the artcile< The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase>, Formula: C3HBrClNS, the main research area is thiazolyl pyridinamine preparation KDR kinase active site mol modeling; pyridinamine thiazolyl preparation KDR kinase ligand.
An azo-dye lead was modified to a N-(1,3-thiazol-2-yl)pyridin-2-amine series of KDR kinase inhibitors through the use of rapid analog libraries. The two lead compounds were N-butyl-N,3-dimethyl-4-[(5-nitro-2-thiazolyl)azo]benzenamine and N-(5-phenyl-2-thiazolyl)benzamide. This class has been found to be potent, selective, and of low mol. weight Mol. modeling has postulated an interesting conformational preference and binding mode for these compounds in the active site of the enzyme. A binding mode was proposed for the lead compound N-(5-phenyl-2-thiazolyl)-2-pyridinamine (I) in the KDR kinase active site.
Bioorganic & Medicinal Chemistry Letters published new progress about Chemical library. 3034-56-8 belongs to class thiazole, and the molecular formula is C3HBrClNS, Formula: C3HBrClNS.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica