Farmer, Luc J.; Bemis, Guy; Britt, Shawn D.; Cochran, John; Connors, Martin; Harrington, Edmund M.; Hoock, Thomas; Markland, William; Nanthakumar, Suganthini; Taslimi, Paul; Ter Haar, Ernst; Wang, Jian; Zhaveri, Darshana; Salituro, Francesco G. published the artcile< Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)>, Electric Literature of 20582-55-2, the main research area is pyrimidine phenylamino thiazolyl derivative preparation tyrosine kinase inhibition SAR; phenylamino pyrimidine thiazole derivative preparation mast cell degranulation inhibition.
A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead, I, were prepared and evaluated for biol. activity. Lead optimization provided compounds with nanomolar Ki’s against SYK and potent inhibition in mast cell degranulation assays.
Bioorganic & Medicinal Chemistry Letters published new progress about Animal gene, c-src Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Electric Literature of 20582-55-2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica