Fu, Xiao-Pu; Xuan, Qing-Qing; Liu, Li; Wang, Dong; Chen, Yong-Jun; Li, Chao-Jun published the artcile< Dual C-H activations of electron-deficient heteroarenes: palladium-catalyzed oxidative cross coupling of thiazoles with azine N-oxides>, Quality Control of 20582-55-2, the main research area is palladium catalyst oxidative cross coupling thiazole azine oxide; thiazolylpyridine oxide preparation.
The palladium-catalyzed, copper-promoted cross-dehydrogenative-coupling (CDC) of electron-deficient thiazoles with azine N-oxides through dual C-H activations was developed. It was found that copper(II) pivalate was an efficient dual-function reagent for the oxidative cross-coupling reactions, playing the roles of both an oxidant and a C-H bond activation promoter. E.g., in presence of Pd(OAc)2 and copper(II) pivalate, oxidative coupling of pyridine N-oxide and 6-methylbenzothiazole gave 70% 2-thiazolylpyridine derivative (I). This methodol. provides a simple way to construct the 2-thiazolylpyridine moiety.
Tetrahedron published new progress about Isotope effect. 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Quality Control of 20582-55-2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica